Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor

Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor

The inflammatory process implicates homeostasis disruption and increased production of inflammatory mediators. Myeloid differentiation primary response 88 (MyD88) is an essential protein recruited after lipopolysaccharide (LPS) and interleukin (IL)-1β stimulation, a process that converges in nuclear...

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Bibliographic Details
Main Authors: Sergio Ramírez-Pérez, Luis Alexis Hernández-Palma, Edith Oregon-Romero, Brian Uriel Anaya-Macías, Samuel García-Arellano, Guillermo González-Estevez, José Francisco Muñoz-Valle
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
ST2825
MyD88 inhibition
cytokine downregulation
PBMC
Online Access:https://www.mdpi.com/1420-3049/25/18/4322

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