Cost-utility analysis of newborn hepatitis B immunization in Beijing
Objectives To evaluate cost-utility of universal Hepatitis B vaccination program in the Beijing city (Beijing). Methods A decision-Markov model was constructed to determine the cost-utility of the universal immunization program for infants (universal vaccination program) by comparing with a hypothet...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-04-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2020.1807812 |
| _version_ | 1797677215348948992 |
|---|---|
| author | Yiwei Guo Yong Yang Qian Bai Zhengwei Huang Zongwu Wang Dongxia Cai Shuo Li Xiaowei Man Xuefeng Shi |
| author_facet | Yiwei Guo Yong Yang Qian Bai Zhengwei Huang Zongwu Wang Dongxia Cai Shuo Li Xiaowei Man Xuefeng Shi |
| author_sort | Yiwei Guo |
| collection | DOAJ |
| description | Objectives To evaluate cost-utility of universal Hepatitis B vaccination program in the Beijing city (Beijing). Methods A decision-Markov model was constructed to determine the cost-utility of the universal immunization program for infants (universal vaccination program) by comparing with a hypothetic nonvaccination strategy in Beijing. Parameters in models were extracted from Beijing Center for Disease Control and Prevention (CDC) annual work report, Beijing health statistical yearbook, National Health Survey report, Beijing 1% population sample survey report, Beijing Health and Medical Price Monitoring Data Platform, and public literatures. The incremental cost‑utility ratio (ICUR) was used to compare alternative scenarios. One-way sensitivity analysis and probabilistic sensitivity analysis were used to assess parameter uncertainties. Results The universal vaccination program had increased the utility and reduced cost among infants born in 2016 in Beijing. The ICUR was CNY −24,576.61 (US$ −3779.16) per QALY for universal vaccination program comparing with non-vaccination scenario from healthcare perspective. It was estimated that the universal vaccination would save direct medical treatment cost of CNY 2,262,869,173.50 (US$ 347,962,414.43) and prevent loss of 18322.25 QALYs within lifetime of target cohort. Discount rate accounted for the most remarkable influence on ICUR in one-way sensitivity analysis. The result of probabilistic sensitivity analysis illustrated that all of the ICURs were located in the fourth quadrant of the cost-utility incremental plot undergone 5000 times of Monte Carlo simulation. Conclusions Current universal hepatitis B vaccination program in Beijing was highly cost utility. The investment was reasonable for current universal vaccination program in Beijing. |
| first_indexed | 2024-03-11T22:41:53Z |
| format | Article |
| id | doaj.art-7153a50029984f2ca971aa6d29bb3859 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:41:53Z |
| publishDate | 2021-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-7153a50029984f2ca971aa6d29bb38592023-09-22T08:51:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-04-011741196120410.1080/21645515.2020.18078121807812Cost-utility analysis of newborn hepatitis B immunization in BeijingYiwei Guo0Yong Yang1Qian Bai2Zhengwei Huang3Zongwu Wang4Dongxia Cai5Shuo Li6Xiaowei Man7Xuefeng Shi8Wuhan UniversityBeijing University of Chinese MedicineUniversity of Macau, Avenida da UniversidadeBeijing University of Chinese MedicineHealth News Co.,LtdBeijing University of Chinese MedicineBeijing University of Chinese MedicineBeijing University of Chinese MedicineBeijing University of Chinese MedicineObjectives To evaluate cost-utility of universal Hepatitis B vaccination program in the Beijing city (Beijing). Methods A decision-Markov model was constructed to determine the cost-utility of the universal immunization program for infants (universal vaccination program) by comparing with a hypothetic nonvaccination strategy in Beijing. Parameters in models were extracted from Beijing Center for Disease Control and Prevention (CDC) annual work report, Beijing health statistical yearbook, National Health Survey report, Beijing 1% population sample survey report, Beijing Health and Medical Price Monitoring Data Platform, and public literatures. The incremental cost‑utility ratio (ICUR) was used to compare alternative scenarios. One-way sensitivity analysis and probabilistic sensitivity analysis were used to assess parameter uncertainties. Results The universal vaccination program had increased the utility and reduced cost among infants born in 2016 in Beijing. The ICUR was CNY −24,576.61 (US$ −3779.16) per QALY for universal vaccination program comparing with non-vaccination scenario from healthcare perspective. It was estimated that the universal vaccination would save direct medical treatment cost of CNY 2,262,869,173.50 (US$ 347,962,414.43) and prevent loss of 18322.25 QALYs within lifetime of target cohort. Discount rate accounted for the most remarkable influence on ICUR in one-way sensitivity analysis. The result of probabilistic sensitivity analysis illustrated that all of the ICURs were located in the fourth quadrant of the cost-utility incremental plot undergone 5000 times of Monte Carlo simulation. Conclusions Current universal hepatitis B vaccination program in Beijing was highly cost utility. The investment was reasonable for current universal vaccination program in Beijing.http://dx.doi.org/10.1080/21645515.2020.1807812hepatitis bvaccinationeconomic evaluationcost-utilitybeijing |
| spellingShingle | Yiwei Guo Yong Yang Qian Bai Zhengwei Huang Zongwu Wang Dongxia Cai Shuo Li Xiaowei Man Xuefeng Shi Cost-utility analysis of newborn hepatitis B immunization in Beijing Human Vaccines & Immunotherapeutics hepatitis b vaccination economic evaluation cost-utility beijing |
| title | Cost-utility analysis of newborn hepatitis B immunization in Beijing |
| title_full | Cost-utility analysis of newborn hepatitis B immunization in Beijing |
| title_fullStr | Cost-utility analysis of newborn hepatitis B immunization in Beijing |
| title_full_unstemmed | Cost-utility analysis of newborn hepatitis B immunization in Beijing |
| title_short | Cost-utility analysis of newborn hepatitis B immunization in Beijing |
| title_sort | cost utility analysis of newborn hepatitis b immunization in beijing |
| topic | hepatitis b vaccination economic evaluation cost-utility beijing |
| url | http://dx.doi.org/10.1080/21645515.2020.1807812 |
| work_keys_str_mv | AT yiweiguo costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT yongyang costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT qianbai costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT zhengweihuang costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT zongwuwang costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT dongxiacai costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT shuoli costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT xiaoweiman costutilityanalysisofnewbornhepatitisbimmunizationinbeijing AT xuefengshi costutilityanalysisofnewbornhepatitisbimmunizationinbeijing |