Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.

Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders.

Gene-environment interactions may play an important role in modulating the impact of early-life stressful events on the clinical course of bipolar disorder (BD), particularly associated to early age at onset. Immune dysfunction is thought to be an important mechanism linking childhood trauma with ea...

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Bibliographic Details
Main Authors: José Oliveira, Bruno Etain, Mohamed Lajnef, Nora Hamdani, Meriem Bennabi, Djaouida Bengoufa, Aparna Sundaresh, Arij Ben Chaabane, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer, Ryad Tamouza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0119702

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