Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021
Incidence of Streptococcus dysgalactiae subspecies equisimilis (SDSE) bacteremia is increasing in the Kyoto-Shiga region of Japan. We retrospectively analyzed clinical features of SDSE bacteremia and conducted comparative genomic analyses of isolates collected from 146 bacteremia episodes among 133...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2023-03-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/3/22-1060_article |
| _version_ | 1797895692692226048 |
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| author | Koh Shinohara Kazunori Murase Yasuhiro Tsuchido Taro Noguchi Satomi Yukawa Masaki Yamamoto Yasufumi Matsumura Ichiro Nakagawa Miki Nagao |
| author_facet | Koh Shinohara Kazunori Murase Yasuhiro Tsuchido Taro Noguchi Satomi Yukawa Masaki Yamamoto Yasufumi Matsumura Ichiro Nakagawa Miki Nagao |
| author_sort | Koh Shinohara |
| collection | DOAJ |
| description |
Incidence of Streptococcus dysgalactiae subspecies equisimilis (SDSE) bacteremia is increasing in the Kyoto-Shiga region of Japan. We retrospectively analyzed clinical features of SDSE bacteremia and conducted comparative genomic analyses of isolates collected from 146 bacteremia episodes among 133 patients during 2005–2021. Of those patients, 7.7% required vasopressor support, and 7.0% died while in the hospital. The prevalence of isolates resistant to erythromycin, minocycline, and clindamycin increased from 8.6% during 2005–2017 to 21.6% during 2018–2021. Our genomic analysis demonstrated that sequence type 525 and clonal complex 25 were predominant in SDSE isolates collected during 2018–2021. In addition, those isolates had acquired 2 antimicrobial-resistance genes, ermB and tetM, via Tn916-like integrative and conjugative elements (ICEs). Phylogenetic analysis revealed clonal distribution of Tn916-like ICEs in SDSE isolates. Our findings suggest that Tn916-like ICEs contributed to the emergence and recent increase of multidrug-resistant SDSE bacteremia in this region of Japan.
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| first_indexed | 2024-04-10T07:29:51Z |
| format | Article |
| id | doaj.art-71563c8b267f4244a833a635e61eb7d7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-10T07:29:51Z |
| publishDate | 2023-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-71563c8b267f4244a833a635e61eb7d72023-02-23T18:06:37ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-03-0129352853910.3201/eid2903.221060Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021Koh ShinoharaKazunori MuraseYasuhiro TsuchidoTaro NoguchiSatomi YukawaMasaki YamamotoYasufumi MatsumuraIchiro NakagawaMiki Nagao Incidence of Streptococcus dysgalactiae subspecies equisimilis (SDSE) bacteremia is increasing in the Kyoto-Shiga region of Japan. We retrospectively analyzed clinical features of SDSE bacteremia and conducted comparative genomic analyses of isolates collected from 146 bacteremia episodes among 133 patients during 2005–2021. Of those patients, 7.7% required vasopressor support, and 7.0% died while in the hospital. The prevalence of isolates resistant to erythromycin, minocycline, and clindamycin increased from 8.6% during 2005–2017 to 21.6% during 2018–2021. Our genomic analysis demonstrated that sequence type 525 and clonal complex 25 were predominant in SDSE isolates collected during 2018–2021. In addition, those isolates had acquired 2 antimicrobial-resistance genes, ermB and tetM, via Tn916-like integrative and conjugative elements (ICEs). Phylogenetic analysis revealed clonal distribution of Tn916-like ICEs in SDSE isolates. Our findings suggest that Tn916-like ICEs contributed to the emergence and recent increase of multidrug-resistant SDSE bacteremia in this region of Japan. https://wwwnc.cdc.gov/eid/article/29/3/22-1060_articleStreptococcus dysgalactiae subspecies equisimilisbacteriaantimicrobial resistancestreptococcibacteremiatransposase |
| spellingShingle | Koh Shinohara Kazunori Murase Yasuhiro Tsuchido Taro Noguchi Satomi Yukawa Masaki Yamamoto Yasufumi Matsumura Ichiro Nakagawa Miki Nagao Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 Emerging Infectious Diseases Streptococcus dysgalactiae subspecies equisimilis bacteria antimicrobial resistance streptococci bacteremia transposase |
| title | Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 |
| title_full | Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 |
| title_fullStr | Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 |
| title_full_unstemmed | Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 |
| title_short | Clonal Expansion of Multidrug-Resistant Streptococcus dysgalactiae Subspecies equisimilis Causing Bacteremia, Japan, 2005–2021 |
| title_sort | clonal expansion of multidrug resistant streptococcus dysgalactiae subspecies equisimilis causing bacteremia japan 2005 2021 |
| topic | Streptococcus dysgalactiae subspecies equisimilis bacteria antimicrobial resistance streptococci bacteremia transposase |
| url | https://wwwnc.cdc.gov/eid/article/29/3/22-1060_article |
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