Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection
The presence of heavy metal ions in soil, air and water constitutes an important global environmental threat, as these ions accumulate throughout the food chain, contributing to the rise of chronic diseases, including, amongst others, cancer and kidney failure. To date, many efforts have been made f...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/14/8/1595 |
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| author | Myrto Kyriaki Filippidou Aris Ioannis Kanaris Evangelos Aslanidis Annita Rapesi Dimitra Tsounidi Sotirios Ntouskas Evangelos Skotadis George Tsekenis Dimitris Tsoukalas Angeliki Tserepi Stavros Chatzandroulis |
| author_facet | Myrto Kyriaki Filippidou Aris Ioannis Kanaris Evangelos Aslanidis Annita Rapesi Dimitra Tsounidi Sotirios Ntouskas Evangelos Skotadis George Tsekenis Dimitris Tsoukalas Angeliki Tserepi Stavros Chatzandroulis |
| author_sort | Myrto Kyriaki Filippidou |
| collection | DOAJ |
| description | The presence of heavy metal ions in soil, air and water constitutes an important global environmental threat, as these ions accumulate throughout the food chain, contributing to the rise of chronic diseases, including, amongst others, cancer and kidney failure. To date, many efforts have been made for their detection, but there is still a need for the development of sensitive, low-cost, and portable devices able to conduct on-site detection of heavy metal ions. In this work, we combine microfluidic technology and electrochemical sensing in a plastic chip for the selective detection of heavy metal ions utilizing DNAzymes immobilized in between platinum nanoparticles (PtNPs), demonstrating a reliable portable solution for water pollution monitoring. For the realization of the microfluidic-based heavy metal ion detection device, a fast and easy-to-implement fabrication method based on the photolithography of dry photosensitive layers is proposed. As a proof of concept, we demonstrate the detection of Pb<sup>2+</sup> ions using the prototype microfluidic device. |
| first_indexed | 2024-03-10T23:43:39Z |
| format | Article |
| id | doaj.art-7156ae23cab4454f9560483ae3eada26 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T23:43:39Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-7156ae23cab4454f9560483ae3eada262023-11-19T02:14:09ZengMDPI AGMicromachines2072-666X2023-08-01148159510.3390/mi14081595Integrated Plastic Microfluidic Device for Heavy Metal Ion DetectionMyrto Kyriaki Filippidou0Aris Ioannis Kanaris1Evangelos Aslanidis2Annita Rapesi3Dimitra Tsounidi4Sotirios Ntouskas5Evangelos Skotadis6George Tsekenis7Dimitris Tsoukalas8Angeliki Tserepi9Stavros Chatzandroulis10Institute of Nanoscience and Nanotechnology, NCSR ‘‘Demokritos’’, 15341 Aghia Paraskevi, GreeceInstitute of Nanoscience and Nanotechnology, NCSR ‘‘Demokritos’’, 15341 Aghia Paraskevi, GreeceDepartment of Applied Sciences, National Technical University of Athens, 15780 Zografou, GreeceDepartment of Applied Sciences, National Technical University of Athens, 15780 Zografou, GreeceBiomedical Research Foundation of the Academy of Athens, 11527 Athens, GreeceInstitute of Nanoscience and Nanotechnology, NCSR ‘‘Demokritos’’, 15341 Aghia Paraskevi, GreeceDepartment of Applied Sciences, National Technical University of Athens, 15780 Zografou, GreeceBiomedical Research Foundation of the Academy of Athens, 11527 Athens, GreeceDepartment of Applied Sciences, National Technical University of Athens, 15780 Zografou, GreeceInstitute of Nanoscience and Nanotechnology, NCSR ‘‘Demokritos’’, 15341 Aghia Paraskevi, GreeceInstitute of Nanoscience and Nanotechnology, NCSR ‘‘Demokritos’’, 15341 Aghia Paraskevi, GreeceThe presence of heavy metal ions in soil, air and water constitutes an important global environmental threat, as these ions accumulate throughout the food chain, contributing to the rise of chronic diseases, including, amongst others, cancer and kidney failure. To date, many efforts have been made for their detection, but there is still a need for the development of sensitive, low-cost, and portable devices able to conduct on-site detection of heavy metal ions. In this work, we combine microfluidic technology and electrochemical sensing in a plastic chip for the selective detection of heavy metal ions utilizing DNAzymes immobilized in between platinum nanoparticles (PtNPs), demonstrating a reliable portable solution for water pollution monitoring. For the realization of the microfluidic-based heavy metal ion detection device, a fast and easy-to-implement fabrication method based on the photolithography of dry photosensitive layers is proposed. As a proof of concept, we demonstrate the detection of Pb<sup>2+</sup> ions using the prototype microfluidic device.https://www.mdpi.com/2072-666X/14/8/1595Lab on a ChipmicrofluidicsmicrofabricationKaptonheavy metal ion detectionDNAzyme |
| spellingShingle | Myrto Kyriaki Filippidou Aris Ioannis Kanaris Evangelos Aslanidis Annita Rapesi Dimitra Tsounidi Sotirios Ntouskas Evangelos Skotadis George Tsekenis Dimitris Tsoukalas Angeliki Tserepi Stavros Chatzandroulis Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection Micromachines Lab on a Chip microfluidics microfabrication Kapton heavy metal ion detection DNAzyme |
| title | Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection |
| title_full | Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection |
| title_fullStr | Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection |
| title_full_unstemmed | Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection |
| title_short | Integrated Plastic Microfluidic Device for Heavy Metal Ion Detection |
| title_sort | integrated plastic microfluidic device for heavy metal ion detection |
| topic | Lab on a Chip microfluidics microfabrication Kapton heavy metal ion detection DNAzyme |
| url | https://www.mdpi.com/2072-666X/14/8/1595 |
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