Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp
Lead, an environmental toxicant in our daily life, has been reported to have adverse effectson human and animals. Previous studies showed lead could accumulate in kidney tissues of carp and cause injury to the kidney tissues. In this study, we aimed to investigate the protective effects of andrograp...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Aquaculture Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513420302908 |
| _version_ | 1828474796812271616 |
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| author | Yue Zhang Peijun Zhang Peng Yu Xinchi Shang Yunhe Fu Yuting Lu Yuehong Li |
| author_facet | Yue Zhang Peijun Zhang Peng Yu Xinchi Shang Yunhe Fu Yuting Lu Yuehong Li |
| author_sort | Yue Zhang |
| collection | DOAJ |
| description | Lead, an environmental toxicant in our daily life, has been reported to have adverse effectson human and animals. Previous studies showed lead could accumulate in kidney tissues of carp and cause injury to the kidney tissues. In this study, we aimed to investigate the protective effects of andrographolide on lead-induced kidney injury in common carp and to clarify the possible mechanism. The results showed that treatment of andrographolide significantly inhibited lead-induced TNF-α and IL-1β production. Meanwhile, the MPO activity and MDA content were also inhibited by andrographolide. The activities of GSH and SOD were decreased and treatment of andrographolide significantly up-regulated GSH and SOD activities. Furthermore, qRT-PCR results showed andrographolide dose-dependently suppressed lead-induced NF-κB activation. Andrographolide increased Nrf2 and HO-1 expression in a dose-dependent manner. In conclusion, this study we found andrographolide could protect carp against lead-induced kidney injury through inhibiting inflammatory and oxidative responses. |
| first_indexed | 2024-12-11T06:04:27Z |
| format | Article |
| id | doaj.art-715ac318c6fa41918043398da6c3bde9 |
| institution | Directory Open Access Journal |
| issn | 2352-5134 |
| language | English |
| last_indexed | 2024-12-11T06:04:27Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj.art-715ac318c6fa41918043398da6c3bde92022-12-22T01:18:21ZengElsevierAquaculture Reports2352-51342020-07-0117100395Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carpYue Zhang0Peijun Zhang1Peng Yu2Xinchi Shang3Yunhe Fu4Yuting Lu5Yuehong Li6Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, ChinaHealth Monitoring and Inspection Center of Jilin Province, Changchun, 130062, ChinaCollege of Electronic and Information Engineering, Changchun University of Science and Technology, Changchun, 130022, ChinaKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, ChinaKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, ChinaKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, ChinaKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China; Corresponding author at: College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China.Lead, an environmental toxicant in our daily life, has been reported to have adverse effectson human and animals. Previous studies showed lead could accumulate in kidney tissues of carp and cause injury to the kidney tissues. In this study, we aimed to investigate the protective effects of andrographolide on lead-induced kidney injury in common carp and to clarify the possible mechanism. The results showed that treatment of andrographolide significantly inhibited lead-induced TNF-α and IL-1β production. Meanwhile, the MPO activity and MDA content were also inhibited by andrographolide. The activities of GSH and SOD were decreased and treatment of andrographolide significantly up-regulated GSH and SOD activities. Furthermore, qRT-PCR results showed andrographolide dose-dependently suppressed lead-induced NF-κB activation. Andrographolide increased Nrf2 and HO-1 expression in a dose-dependent manner. In conclusion, this study we found andrographolide could protect carp against lead-induced kidney injury through inhibiting inflammatory and oxidative responses.http://www.sciencedirect.com/science/article/pii/S2352513420302908LeadCarpAndrographolideNrf2NF-κB |
| spellingShingle | Yue Zhang Peijun Zhang Peng Yu Xinchi Shang Yunhe Fu Yuting Lu Yuehong Li Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp Aquaculture Reports Lead Carp Andrographolide Nrf2 NF-κB |
| title | Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| title_full | Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| title_fullStr | Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| title_full_unstemmed | Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| title_short | Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| title_sort | protective effects of andrographolide on lead induced kidney injury through inhibiting inflammatory and oxidative responses in common carp |
| topic | Lead Carp Andrographolide Nrf2 NF-κB |
| url | http://www.sciencedirect.com/science/article/pii/S2352513420302908 |
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