HLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection

HLA-E restricted cytomegalovirus UL40 peptide polymorphism may represent a risk factor following congenital infection

Abstract Background Congenital cytomegalovirus immunopathogenesis is largely unknown and multifactorial due to the complex interactions between viral, maternal, placental, and child factors. Polymorphisms in the HLA-E binding UL4015-23 peptide mimics HLA-E complexed peptides from certain HLA-A, -B,...

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Bibliographic Details
Main Authors: David Tarragó, Irene González, Maria Francisca González-Escribano
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Genomics
Subjects:
Congenital CMV
UL40 peptide
Immunomodulatory gene
UL40 variability
HLA-E
Online Access:https://doi.org/10.1186/s12864-022-08689-0

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