Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise
McArdle’s disease, known as blockage of muscle glycogen metabolism, is characterized by glycogen accumulation of chains in skeletal striated muscles. One of the typical symptoms of the disease is the feeling of intolerance to exercise. Severe muscle cram and contracture, which often cause stiffness,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=7;spage=91;epage=99;aulast=Dantas |
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| author | Guilherme Henrique Mattos Dantas Artur Luís Bessa de Oliveira Pablo Jorge Marcos-Pardo Vanessa Franco Ferreira Coutinho Felipe Cassau de Sá Freire Juliana Brandão Pinto de Castro Rodrigo Gomes de Souza Vale |
| author_facet | Guilherme Henrique Mattos Dantas Artur Luís Bessa de Oliveira Pablo Jorge Marcos-Pardo Vanessa Franco Ferreira Coutinho Felipe Cassau de Sá Freire Juliana Brandão Pinto de Castro Rodrigo Gomes de Souza Vale |
| author_sort | Guilherme Henrique Mattos Dantas |
| collection | DOAJ |
| description | McArdle’s disease, known as blockage of muscle glycogen metabolism, is characterized by glycogen accumulation of chains in skeletal striated muscles. One of the typical symptoms of the disease is the feeling of intolerance to exercise. Severe muscle cram and contracture, which often cause stiffness, occur due to a lack of muscle energy substrate during the exercise. These factors can lead to muscle damage, myoglobinuria, and, in severe cases, renal failure and rhabdomyolysis. Rhabdomyolysis is a syndrome that presents injury and necrosis of muscle cells leading to the release of intracellular material to the circulatory system. The present study aimed to report rhabdomyolysis in an individual with McArdle’s disease after exercise of walking with low intensity. Patient, aged 33 years, was treated in the emergency room of a hospital located in the State of Rio de Janeiro, Brazil. After performing a full lap on the block of home (~500 m in ~4 min 37 s), walking at a moderate speed (~6.5 km/h), the individual felt sick and was rescued, later being hospitalized. The examinations collected presented hematocrit (HCT) compatible with chronic disease anemia and myoglobinuria. The patient was discharged from the intensive care center on the 3rd day, after a 45% drop in creatine kinase. The patient described in the present study achieved full recovery. Attention to symptoms, early diagnosis, and immediate treatment made it possible to interrupt the development of complications caused by rhabdomyolysis, not allowing progression to acute renal failure. |
| first_indexed | 2024-03-12T22:34:30Z |
| format | Article |
| id | doaj.art-716273170fff4e069e9b2ef1392299be |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-03-12T22:34:30Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-716273170fff4e069e9b2ef1392299be2023-07-21T13:05:40ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422022-01-01337919910.4103/1319-2442.374387Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic ExerciseGuilherme Henrique Mattos DantasArtur Luís Bessa de OliveiraPablo Jorge Marcos-PardoVanessa Franco Ferreira CoutinhoFelipe Cassau de Sá FreireJuliana Brandão Pinto de CastroRodrigo Gomes de Souza ValeMcArdle’s disease, known as blockage of muscle glycogen metabolism, is characterized by glycogen accumulation of chains in skeletal striated muscles. One of the typical symptoms of the disease is the feeling of intolerance to exercise. Severe muscle cram and contracture, which often cause stiffness, occur due to a lack of muscle energy substrate during the exercise. These factors can lead to muscle damage, myoglobinuria, and, in severe cases, renal failure and rhabdomyolysis. Rhabdomyolysis is a syndrome that presents injury and necrosis of muscle cells leading to the release of intracellular material to the circulatory system. The present study aimed to report rhabdomyolysis in an individual with McArdle’s disease after exercise of walking with low intensity. Patient, aged 33 years, was treated in the emergency room of a hospital located in the State of Rio de Janeiro, Brazil. After performing a full lap on the block of home (~500 m in ~4 min 37 s), walking at a moderate speed (~6.5 km/h), the individual felt sick and was rescued, later being hospitalized. The examinations collected presented hematocrit (HCT) compatible with chronic disease anemia and myoglobinuria. The patient was discharged from the intensive care center on the 3rd day, after a 45% drop in creatine kinase. The patient described in the present study achieved full recovery. Attention to symptoms, early diagnosis, and immediate treatment made it possible to interrupt the development of complications caused by rhabdomyolysis, not allowing progression to acute renal failure.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=7;spage=91;epage=99;aulast=Dantas |
| spellingShingle | Guilherme Henrique Mattos Dantas Artur Luís Bessa de Oliveira Pablo Jorge Marcos-Pardo Vanessa Franco Ferreira Coutinho Felipe Cassau de Sá Freire Juliana Brandão Pinto de Castro Rodrigo Gomes de Souza Vale Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise Saudi Journal of Kidney Diseases and Transplantation |
| title | Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise |
| title_full | Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise |
| title_fullStr | Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise |
| title_full_unstemmed | Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise |
| title_short | Rhabdomyolysis Episode in an Individual with McArdle’s Disease after Low Aerobic Exercise |
| title_sort | rhabdomyolysis episode in an individual with mcardle s disease after low aerobic exercise |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2022;volume=33;issue=7;spage=91;epage=99;aulast=Dantas |
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