Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities
Over the past few decades (covering 1972 to 2022), astounding progress has been made in the elucidation of structures, bioactivities and biosynthesis of polyene macrolactams (PMLs), but they have only been partially summarized. PMLs possess a wide range of biological activities, particularly distinc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/6/360 |
| _version_ | 1827659018960633856 |
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| author | Wei Zhao Hong Jiang Xiao-Wan Liu Jian Zhou Bin Wu |
| author_facet | Wei Zhao Hong Jiang Xiao-Wan Liu Jian Zhou Bin Wu |
| author_sort | Wei Zhao |
| collection | DOAJ |
| description | Over the past few decades (covering 1972 to 2022), astounding progress has been made in the elucidation of structures, bioactivities and biosynthesis of polyene macrolactams (PMLs), but they have only been partially summarized. PMLs possess a wide range of biological activities, particularly distinctive fungal inhibitory abilities, which render them a promising drug candidate. Moreover, the unique biosynthetic pathways including β-amino acid initiation and pericyclic reactions were presented in PMLs, leading to more attention from inside and outside the natural products community. According to current summation, in this review, the chem- and bio-diversity of PMLs from marine and terrestrial sources are considerably rich. A systematic, critical and comprehensive overview is in great need. This review described the PMLs’ general structural features, production strategies, biosynthetic pathways and the mechanisms of bioactivities. The challenges and opportunities for the research of PMLs are also discussed. |
| first_indexed | 2024-03-09T23:13:41Z |
| format | Article |
| id | doaj.art-71678a44ca244e748b94ce8ec127a6c5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T23:13:41Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-71678a44ca244e748b94ce8ec127a6c52023-11-23T17:40:53ZengMDPI AGMarine Drugs1660-33972022-05-0120636010.3390/md20060360Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and BioactivitiesWei Zhao0Hong Jiang1Xiao-Wan Liu2Jian Zhou3Bin Wu4Polytechnic Institute, Zhejiang University, Hangzhou 310015, ChinaFujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou 350007, ChinaThe State Key Laboratory of Marine Pollution and Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR 999077, ChinaFujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou 350007, ChinaOcean College, Zhejiang University, Zhoushan 321000, ChinaOver the past few decades (covering 1972 to 2022), astounding progress has been made in the elucidation of structures, bioactivities and biosynthesis of polyene macrolactams (PMLs), but they have only been partially summarized. PMLs possess a wide range of biological activities, particularly distinctive fungal inhibitory abilities, which render them a promising drug candidate. Moreover, the unique biosynthetic pathways including β-amino acid initiation and pericyclic reactions were presented in PMLs, leading to more attention from inside and outside the natural products community. According to current summation, in this review, the chem- and bio-diversity of PMLs from marine and terrestrial sources are considerably rich. A systematic, critical and comprehensive overview is in great need. This review described the PMLs’ general structural features, production strategies, biosynthetic pathways and the mechanisms of bioactivities. The challenges and opportunities for the research of PMLs are also discussed.https://www.mdpi.com/1660-3397/20/6/360polyene macrolactams (PMLs)structural featuresacquisition strategiesbiosynthetic pathwaysmechanismschallenges and opportunities |
| spellingShingle | Wei Zhao Hong Jiang Xiao-Wan Liu Jian Zhou Bin Wu Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities Marine Drugs polyene macrolactams (PMLs) structural features acquisition strategies biosynthetic pathways mechanisms challenges and opportunities |
| title | Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities |
| title_full | Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities |
| title_fullStr | Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities |
| title_full_unstemmed | Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities |
| title_short | Polyene Macrolactams from Marine and Terrestrial Sources: Structure, Production Strategies, Biosynthesis and Bioactivities |
| title_sort | polyene macrolactams from marine and terrestrial sources structure production strategies biosynthesis and bioactivities |
| topic | polyene macrolactams (PMLs) structural features acquisition strategies biosynthetic pathways mechanisms challenges and opportunities |
| url | https://www.mdpi.com/1660-3397/20/6/360 |
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