Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review
ObjectivesGut dysbiosis is believed to be one of the several mechanisms that are involved in the pathogenesis of gout. This systematic review aimed to summarize the role of gut dysbiosis in gout disease and uncover the underlying mechanisms.MethodsA comprehensive search was conducted on PubMed, Web...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1163778/full |
| _version_ | 1827946132426194944 |
|---|---|
| author | Salman Shirvani-Rad Salman Shirvani-Rad Niloufar Khatibzade-Nasari Niloufar Khatibzade-Nasari Hanieh-Sadat Ejtahed Bagher Larijani |
| author_facet | Salman Shirvani-Rad Salman Shirvani-Rad Niloufar Khatibzade-Nasari Niloufar Khatibzade-Nasari Hanieh-Sadat Ejtahed Bagher Larijani |
| author_sort | Salman Shirvani-Rad |
| collection | DOAJ |
| description | ObjectivesGut dysbiosis is believed to be one of the several mechanisms that are involved in the pathogenesis of gout. This systematic review aimed to summarize the role of gut dysbiosis in gout disease and uncover the underlying mechanisms.MethodsA comprehensive search was conducted on PubMed, Web of Science, and Scopus databases up to October 2021. Animal studies and human observational studies, including case-control, cross-sectional, and cohort studies assessing the association between gut microbiota composition and gout were included. The quality of included studies has been evaluated using the Newcastle–Ottawa Quality Assessment scale (NOS) and the SYRCLE's risk of bias tool.ResultsInitially, we found 274 studies among which 15 studies were included in this systematic review. Of them, 10 studies were conducted on humans and 5 studies were conducted on animals. Increased abundance of Alistipes and decreased abundance of Enterobacteriaceae alters purine metabolism, thereby aggravating gout condition. Moreover, a higher abundance of Phascolarctobacterium and Bacteroides in gout modulates enzymatic activity in purine metabolism. Butyrate-producing bacteria such as Faecalibacterium, prausnitzii, Oscillibacter, Butyricicoccus, and Bifidobacterium have higher abundance in healthy controls compared to gout patients, suggesting the anti-inflammatory and anti-microbial role of short-chain fatty acids (SCFAs). Lipopolysaccharides (LPS)-releasing bacteria, such as Enterobacteriaceae, Prevotella, and Bacteroides, are also involved in the pathogenesis of gout disease by stimulating the innate immune system.ConclusionExploring the role of gut dysbiosis in gout and the underlying mechanisms can help develop microbiota-modulating therapies for gout. |
| first_indexed | 2024-03-13T10:54:22Z |
| format | Article |
| id | doaj.art-71685cef3de0481dad4379c0411dc5da |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T10:54:22Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-71685cef3de0481dad4379c0411dc5da2023-05-17T05:37:40ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11637781163778Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic reviewSalman Shirvani-Rad0Salman Shirvani-Rad1Niloufar Khatibzade-Nasari2Niloufar Khatibzade-Nasari3Hanieh-Sadat Ejtahed4Bagher Larijani5Microbiota Research Group, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranFaculty of Medicine, Qeshm International Medical Sciences Branch, Islamic Azad University, Qeshm, IranFaculty of Medicine, Qeshm International Medical Sciences Branch, Islamic Azad University, Qeshm, IranYoung Researchers and Elite Club, Qeshm International Medical Sciences Branch, Islamic Azad University, Qeshm, IranObesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, IranObjectivesGut dysbiosis is believed to be one of the several mechanisms that are involved in the pathogenesis of gout. This systematic review aimed to summarize the role of gut dysbiosis in gout disease and uncover the underlying mechanisms.MethodsA comprehensive search was conducted on PubMed, Web of Science, and Scopus databases up to October 2021. Animal studies and human observational studies, including case-control, cross-sectional, and cohort studies assessing the association between gut microbiota composition and gout were included. The quality of included studies has been evaluated using the Newcastle–Ottawa Quality Assessment scale (NOS) and the SYRCLE's risk of bias tool.ResultsInitially, we found 274 studies among which 15 studies were included in this systematic review. Of them, 10 studies were conducted on humans and 5 studies were conducted on animals. Increased abundance of Alistipes and decreased abundance of Enterobacteriaceae alters purine metabolism, thereby aggravating gout condition. Moreover, a higher abundance of Phascolarctobacterium and Bacteroides in gout modulates enzymatic activity in purine metabolism. Butyrate-producing bacteria such as Faecalibacterium, prausnitzii, Oscillibacter, Butyricicoccus, and Bifidobacterium have higher abundance in healthy controls compared to gout patients, suggesting the anti-inflammatory and anti-microbial role of short-chain fatty acids (SCFAs). Lipopolysaccharides (LPS)-releasing bacteria, such as Enterobacteriaceae, Prevotella, and Bacteroides, are also involved in the pathogenesis of gout disease by stimulating the innate immune system.ConclusionExploring the role of gut dysbiosis in gout and the underlying mechanisms can help develop microbiota-modulating therapies for gout.https://www.frontiersin.org/articles/10.3389/fmed.2023.1163778/fullgoutgut microbiotamicrobiomedysbiosishyperuricemia |
| spellingShingle | Salman Shirvani-Rad Salman Shirvani-Rad Niloufar Khatibzade-Nasari Niloufar Khatibzade-Nasari Hanieh-Sadat Ejtahed Bagher Larijani Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review Frontiers in Medicine gout gut microbiota microbiome dysbiosis hyperuricemia |
| title | Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review |
| title_full | Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review |
| title_fullStr | Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review |
| title_full_unstemmed | Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review |
| title_short | Exploring the role of gut microbiota dysbiosis in gout pathogenesis: a systematic review |
| title_sort | exploring the role of gut microbiota dysbiosis in gout pathogenesis a systematic review |
| topic | gout gut microbiota microbiome dysbiosis hyperuricemia |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1163778/full |
| work_keys_str_mv | AT salmanshirvanirad exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview AT salmanshirvanirad exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview AT niloufarkhatibzadenasari exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview AT niloufarkhatibzadenasari exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview AT haniehsadatejtahed exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview AT bagherlarijani exploringtheroleofgutmicrobiotadysbiosisingoutpathogenesisasystematicreview |