Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified. Methods: We report 4 sequential cases from a post-COVID cohort study demonstrating variability in outcomes following differentiall...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Case Western Reserve University
2022-06-01
|
| Series: | Pathogens and Immunity |
| Subjects: | |
| Online Access: | https://www.paijournal.com/index.php/paijournal/article/view/518 |
| _version_ | 1828151118111178752 |
|---|---|
| author | Michael Peluso Khamal Anglin Matthew S. Durstenfeld Jeffrey N. Martin J. Daniel Kelly Priscilla Y. Hsue Timothy J. Henrich Steven G. Deeks |
| author_facet | Michael Peluso Khamal Anglin Matthew S. Durstenfeld Jeffrey N. Martin J. Daniel Kelly Priscilla Y. Hsue Timothy J. Henrich Steven G. Deeks |
| author_sort | Michael Peluso |
| collection | DOAJ |
| description |
Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified.
Methods: We report 4 sequential cases from a post-COVID cohort study demonstrating variability in outcomes following differentially timed nirmatrelvir therapy, received as part of clinical care.
Results: In the first case, the participant experienced symptomatic rebound and developed Long COVID despite early initiation of antiviral therapy. In the next 2 cases, participants reported improvement in persistent COVID symptoms when nirmatrelvir was taken 25 and 60 days following initial symptom onset. In the final case, an individual with presumed Long COVID for 2 years reported substantial improvement in chronic symptoms when taking nirmatrelvir following SARS-CoV-2 re-infection.
Conclusions: These anecdotes suggest that systematic study of antiviral therapy for Long COVID is warranted.
|
| first_indexed | 2024-04-11T21:53:13Z |
| format | Article |
| id | doaj.art-7168969bc6034d9cb6df09a3d96f3fc5 |
| institution | Directory Open Access Journal |
| issn | 2469-2964 |
| language | English |
| last_indexed | 2024-04-11T21:53:13Z |
| publishDate | 2022-06-01 |
| publisher | Case Western Reserve University |
| record_format | Article |
| series | Pathogens and Immunity |
| spelling | doaj.art-7168969bc6034d9cb6df09a3d96f3fc52022-12-22T04:01:11ZengCase Western Reserve UniversityPathogens and Immunity2469-29642022-06-017110.20411/pai.v7i1.518Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic StudiesMichael Peluso0Khamal Anglin1Matthew S. Durstenfeld2Jeffrey N. Martin3J. Daniel Kelly4Priscilla Y. Hsue5Timothy J. Henrich6Steven G. Deeks7Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CADepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CADivision of Cardiology, University of California, San Francisco, San Francisco, CADepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CADepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CADivision of Cardiology, University of California, San Francisco, San Francisco, CADivision of Experimental Medicine, University of California, San Francisco, San Francisco, CADivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA Background: Efforts to understand the impact of SARS-CoV-2 variants, vaccine status, and treatment on the development and persistence of Long COVID have intensified. Methods: We report 4 sequential cases from a post-COVID cohort study demonstrating variability in outcomes following differentially timed nirmatrelvir therapy, received as part of clinical care. Results: In the first case, the participant experienced symptomatic rebound and developed Long COVID despite early initiation of antiviral therapy. In the next 2 cases, participants reported improvement in persistent COVID symptoms when nirmatrelvir was taken 25 and 60 days following initial symptom onset. In the final case, an individual with presumed Long COVID for 2 years reported substantial improvement in chronic symptoms when taking nirmatrelvir following SARS-CoV-2 re-infection. Conclusions: These anecdotes suggest that systematic study of antiviral therapy for Long COVID is warranted. https://www.paijournal.com/index.php/paijournal/article/view/518SARS-CoV-2;Long COVID;post-acute sequelae of SARS-CoV-2 (PASC);antiviral therapy;nirmatrelvir;Paxlovid |
| spellingShingle | Michael Peluso Khamal Anglin Matthew S. Durstenfeld Jeffrey N. Martin J. Daniel Kelly Priscilla Y. Hsue Timothy J. Henrich Steven G. Deeks Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies Pathogens and Immunity SARS-CoV-2; Long COVID; post-acute sequelae of SARS-CoV-2 (PASC); antiviral therapy; nirmatrelvir; Paxlovid |
| title | Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies |
| title_full | Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies |
| title_fullStr | Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies |
| title_full_unstemmed | Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies |
| title_short | Effect of Oral Nirmatrelvir on Long COVID Symptoms: 4 Cases and Rationale for Systematic Studies |
| title_sort | effect of oral nirmatrelvir on long covid symptoms 4 cases and rationale for systematic studies |
| topic | SARS-CoV-2; Long COVID; post-acute sequelae of SARS-CoV-2 (PASC); antiviral therapy; nirmatrelvir; Paxlovid |
| url | https://www.paijournal.com/index.php/paijournal/article/view/518 |
| work_keys_str_mv | AT michaelpeluso effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT khamalanglin effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT matthewsdurstenfeld effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT jeffreynmartin effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT jdanielkelly effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT priscillayhsue effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT timothyjhenrich effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies AT stevengdeeks effectoforalnirmatrelvironlongcovidsymptoms4casesandrationaleforsystematicstudies |