Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose
BackgroundPrevious research indicated that isomers and alternatives of per- and polyfluoroalkyl substances (PFAS) probably disturb glucose metabolism; however, current epidemiological evidence on the associations of PFAS with fasting blood glucose is inconsistent. Besides, studies on the joint assoc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Editorial Committee of Journal of Environmental and Occupational Medicine
2023-10-01
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| Series: | 环境与职业医学 |
| Subjects: | |
| Online Access: | http://www.jeom.org/article/cn/10.11836/JEOM23021 |
| _version_ | 1827620308041859072 |
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| author | Weile HUANG Yanhong XIE Honglian DENG Guanghui DONG Yunting ZHANG Shuli XU |
| author_facet | Weile HUANG Yanhong XIE Honglian DENG Guanghui DONG Yunting ZHANG Shuli XU |
| author_sort | Weile HUANG |
| collection | DOAJ |
| description | BackgroundPrevious research indicated that isomers and alternatives of per- and polyfluoroalkyl substances (PFAS) probably disturb glucose metabolism; however, current epidemiological evidence on the associations of PFAS with fasting blood glucose is inconsistent. Besides, studies on the joint association of multiple components of PFAS and fasting blood glucose as well as the key component are scarce. ObjectiveTo evaluate the associations of PFAS isomers and alternatives with fasting blood glucose and their joint effects, as well as identify the key component among population without glucose metabolism problems. MethodsWe selected 923 adults without glucose metabolism problems or missing data from the Isomers of C8 Health Project in China (2015—2016). Serum PFAS isomers and alternatives and fasting blood glucose were measured using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) and automatic biochemical analyzer. We applied multiple linear regression to explore the associations of 16 pollutants which were detected among over 80% participants with fasting blood glucose. Meanwhile, we utilized qgcomp and Bayesian kernel machine regression (BKMR) models to explore the joint effects of PFAS isomers and alternatives mixture on target outcome indicators and identify the key component. ResultsThe average age among the 923 participants in this study was (62.4±13.8) years old, including 472 men (51.1%) and 451 women (48.9%). Among selected PFAS isomers and alternatives, the highest serum concentration was ∑3+4+5m-PFOS (perfluoro-3/4/5-methylheptanesulfonate) with a median concentration of 10.20 ng·mL−1. The concentrations of linear perfluorooctane sulfonate (n-PFOS, 9.61 ng·mL−1), perfluorooctanoic acid (PFOA, 4.55 ng·mL−1), linear perfluorohexane sulfonic acid (n-PFHxS, 2.48 ng·mL−1), 6:2 chlorinated polyfluorinated ethersulfonic acid (6:2 Cl-PFESA, 1.90 ng·mL−1), perfluoro-6-methylheptanesulfonate (iso-PFOS, 1.85 ng·mL−1), perfluorobutanoic acid (PFBA, 1.81 ng·mL−1), perfluorinated n-nonanoic acid (PFNA, 1.39 ng·mL−1), and perfluoro-1-methylheptanesulfonate (1m-PFOS, 1.27 ng·mL−1) were higher than 1.00 ng·mL−1. After being adjusted for selected confounders, PFAS isomers and alternatives were positively associated with fasting blood glucose. With 1 ln unit concentration increment of 6:2 Cl-PFESA and PFNA, the estimated changes of fasting blood glucose were 0.18 (95%CI: 0.13, 0.23) mmol·L−1 and 0.24 (95%CI: 0.18, 0.30) mmol·L−1, respectively. The multi-pollutant models indicated a joint association of PFAS isomers and alternatives mixture with fasting blood glucose. The BKMR models reveals that as the quantiles of mixture elevated from the 50th to the 75th percentile, the values of fasting blood glucose increased 0.25 (95%CI: 0.21, 0.30) mmol·L−1, and the posterior inclusion probability of PFNA was 0.92, implying that PFNA was the key component. ConclusionPFAS isomers and alternatives are positively associated with fasting blood glucose. PFNA is the key component of the joint association. |
| first_indexed | 2024-03-09T10:45:31Z |
| format | Article |
| id | doaj.art-7169369e34cb453d90867472b874fc57 |
| institution | Directory Open Access Journal |
| issn | 2095-9982 |
| language | English |
| last_indexed | 2024-03-09T10:45:31Z |
| publishDate | 2023-10-01 |
| publisher | Editorial Committee of Journal of Environmental and Occupational Medicine |
| record_format | Article |
| series | 环境与职业医学 |
| spelling | doaj.art-7169369e34cb453d90867472b874fc572023-12-01T10:30:50ZengEditorial Committee of Journal of Environmental and Occupational Medicine环境与职业医学2095-99822023-10-0140101175118210.11836/JEOM2302123021Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucoseWeile HUANG0Yanhong XIE1Honglian DENG2Guanghui DONG3Yunting ZHANG4Shuli XU5Shiyan Subcenter for Public Health Service in Bao’an District, Shenzhen, Guangdong 518108, ChinaShiyan Subcenter for Public Health Service in Bao’an District, Shenzhen, Guangdong 518108, ChinaShiyan Subcenter for Public Health Service in Bao’an District, Shenzhen, Guangdong 518108, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, ChinaShiyan Subcenter for Public Health Service in Bao’an District, Shenzhen, Guangdong 518108, ChinaBackgroundPrevious research indicated that isomers and alternatives of per- and polyfluoroalkyl substances (PFAS) probably disturb glucose metabolism; however, current epidemiological evidence on the associations of PFAS with fasting blood glucose is inconsistent. Besides, studies on the joint association of multiple components of PFAS and fasting blood glucose as well as the key component are scarce. ObjectiveTo evaluate the associations of PFAS isomers and alternatives with fasting blood glucose and their joint effects, as well as identify the key component among population without glucose metabolism problems. MethodsWe selected 923 adults without glucose metabolism problems or missing data from the Isomers of C8 Health Project in China (2015—2016). Serum PFAS isomers and alternatives and fasting blood glucose were measured using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) and automatic biochemical analyzer. We applied multiple linear regression to explore the associations of 16 pollutants which were detected among over 80% participants with fasting blood glucose. Meanwhile, we utilized qgcomp and Bayesian kernel machine regression (BKMR) models to explore the joint effects of PFAS isomers and alternatives mixture on target outcome indicators and identify the key component. ResultsThe average age among the 923 participants in this study was (62.4±13.8) years old, including 472 men (51.1%) and 451 women (48.9%). Among selected PFAS isomers and alternatives, the highest serum concentration was ∑3+4+5m-PFOS (perfluoro-3/4/5-methylheptanesulfonate) with a median concentration of 10.20 ng·mL−1. The concentrations of linear perfluorooctane sulfonate (n-PFOS, 9.61 ng·mL−1), perfluorooctanoic acid (PFOA, 4.55 ng·mL−1), linear perfluorohexane sulfonic acid (n-PFHxS, 2.48 ng·mL−1), 6:2 chlorinated polyfluorinated ethersulfonic acid (6:2 Cl-PFESA, 1.90 ng·mL−1), perfluoro-6-methylheptanesulfonate (iso-PFOS, 1.85 ng·mL−1), perfluorobutanoic acid (PFBA, 1.81 ng·mL−1), perfluorinated n-nonanoic acid (PFNA, 1.39 ng·mL−1), and perfluoro-1-methylheptanesulfonate (1m-PFOS, 1.27 ng·mL−1) were higher than 1.00 ng·mL−1. After being adjusted for selected confounders, PFAS isomers and alternatives were positively associated with fasting blood glucose. With 1 ln unit concentration increment of 6:2 Cl-PFESA and PFNA, the estimated changes of fasting blood glucose were 0.18 (95%CI: 0.13, 0.23) mmol·L−1 and 0.24 (95%CI: 0.18, 0.30) mmol·L−1, respectively. The multi-pollutant models indicated a joint association of PFAS isomers and alternatives mixture with fasting blood glucose. The BKMR models reveals that as the quantiles of mixture elevated from the 50th to the 75th percentile, the values of fasting blood glucose increased 0.25 (95%CI: 0.21, 0.30) mmol·L−1, and the posterior inclusion probability of PFNA was 0.92, implying that PFNA was the key component. ConclusionPFAS isomers and alternatives are positively associated with fasting blood glucose. PFNA is the key component of the joint association.http://www.jeom.org/article/cn/10.11836/JEOM23021per- and polyfluoroalkyl substancesisomeraltenativefating blood glucosemulti-pollutant model |
| spellingShingle | Weile HUANG Yanhong XIE Honglian DENG Guanghui DONG Yunting ZHANG Shuli XU Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose 环境与职业医学 per- and polyfluoroalkyl substances isomer altenative fating blood glucose multi-pollutant model |
| title | Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose |
| title_full | Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose |
| title_fullStr | Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose |
| title_full_unstemmed | Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose |
| title_short | Associations between isomers and alternatives of per- and polyfluoroalkyl substances and fasting blood glucose |
| title_sort | associations between isomers and alternatives of per and polyfluoroalkyl substances and fasting blood glucose |
| topic | per- and polyfluoroalkyl substances isomer altenative fating blood glucose multi-pollutant model |
| url | http://www.jeom.org/article/cn/10.11836/JEOM23021 |
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