The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress
Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of meta...
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6902 |
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| author | Adam Włodarski Justyna Strycharz Adam Wróblewski Jacek Kasznicki Józef Drzewoski Agnieszka Śliwińska |
| author_facet | Adam Włodarski Justyna Strycharz Adam Wróblewski Jacek Kasznicki Józef Drzewoski Agnieszka Śliwińska |
| author_sort | Adam Włodarski |
| collection | DOAJ |
| description | Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS. |
| first_indexed | 2024-03-10T16:11:38Z |
| format | Article |
| id | doaj.art-716946eb8f9e45fa86b22e0590706def |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:11:38Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-716946eb8f9e45fa86b22e0590706def2023-11-20T14:25:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118690210.3390/ijms21186902The Role of microRNAs in Metabolic Syndrome-Related Oxidative StressAdam Włodarski0Justyna Strycharz1Adam Wróblewski2Jacek Kasznicki3Józef Drzewoski4Agnieszka Śliwińska5Department of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, 92-213 Lodz, PolandDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Medical Biochemistry, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Internal Diseases, Diabetology and Clinical Pharmacology, Medical University of Lodz, 92-213 Lodz, PolandCentral Teaching Hospital of the Medical University of Lodz, 92-213 Lodz, PolandDepartment of Nucleic Acid Biochemistry, Medical University of Lodz, 92-213 Lodz, PolandOxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.https://www.mdpi.com/1422-0067/21/18/6902microRNAsoxidative stressreactive oxygen speciesprooxidant enzymesantioxidative enzymesantioxidative genes |
| spellingShingle | Adam Włodarski Justyna Strycharz Adam Wróblewski Jacek Kasznicki Józef Drzewoski Agnieszka Śliwińska The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress International Journal of Molecular Sciences microRNAs oxidative stress reactive oxygen species prooxidant enzymes antioxidative enzymes antioxidative genes |
| title | The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress |
| title_full | The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress |
| title_fullStr | The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress |
| title_full_unstemmed | The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress |
| title_short | The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress |
| title_sort | role of micrornas in metabolic syndrome related oxidative stress |
| topic | microRNAs oxidative stress reactive oxygen species prooxidant enzymes antioxidative enzymes antioxidative genes |
| url | https://www.mdpi.com/1422-0067/21/18/6902 |
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