The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus
Although scientific evidence has shown that natural mineral waters have potential beneficial metabolic effects, there is still very scarce data on their influence on type 2 diabetes mellitus (T2DM). The study was designed to investigate the effects of low mineral water from the “Sneznik-1/79″ source...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023059339 |
| _version_ | 1797732999179010048 |
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| author | Nikola Jovicic Marijana Andjic Jovana Novakovic Nevena Jeremic Vladimir Zivkovic Ivan Srejovic Dejan Stanojevic Petar Ristic Sergey Bolevich Vladimir Jakovljevic |
| author_facet | Nikola Jovicic Marijana Andjic Jovana Novakovic Nevena Jeremic Vladimir Zivkovic Ivan Srejovic Dejan Stanojevic Petar Ristic Sergey Bolevich Vladimir Jakovljevic |
| author_sort | Nikola Jovicic |
| collection | DOAJ |
| description | Although scientific evidence has shown that natural mineral waters have potential beneficial metabolic effects, there is still very scarce data on their influence on type 2 diabetes mellitus (T2DM). The study was designed to investigate the effects of low mineral water from the “Sneznik-1/79″ source in Serbia on microbiota, metabolic, and oxidative stress parameters in patients with T2DM. In total, 60 patients with confirmed T2DM were included in the study, and they consumed “Sneznik-1/79″ water for 28 days. To examine the positive effects of “Sneznik-1/79″ water, we compared the results before and after the four weeks of “Sneznik-1/79″ water intake. Standard biochemical analyses were carried out, such as glucose level, lipid profile, and stool tests. The blood samples were collected to evaluate the effects of “Sneznik-1/79″ water on the redox status. At the end of the monitoring period, the total cholesterol concentration significantly dropped compared to the initial value. A significant improvement in intestinal peristalsis was observed, which was reflected in the fact that after four weeks, all patients established regular, daily bowel movements. Moreover, consumption of “Sneznik-1/79″ water eliminated the appearance of dysbiosis in 50% of patients. Additionally, the antioxidant capacity was improved by increasing the concentration of superoxide dismutase and reduced glutathione. The result of our study pointed out that the intake of “Sneznik-1/79″ water could be a promising adjuvant therapy for improving intestinal peristalsis as well as reducing the appearance of dysbiosis in T2DM patients. |
| first_indexed | 2024-03-12T12:21:41Z |
| format | Article |
| id | doaj.art-716aa066c7e942bbbc5e46cf438fcc73 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-12T12:21:41Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-716aa066c7e942bbbc5e46cf438fcc732023-08-30T05:52:21ZengElsevierHeliyon2405-84402023-08-0198e18725The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitusNikola Jovicic0Marijana Andjic1Jovana Novakovic2Nevena Jeremic3Vladimir Zivkovic4Ivan Srejovic5Dejan Stanojevic6Petar Ristic7Sergey Bolevich8Vladimir Jakovljevic9Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; 1st Moscow State Medical, University IM Sechenov, Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Pharmacology, Institute of Biodesign and Complex System Modelling, First Moscow State Medical University I.M. Sechenov, Moscow, Russia; Corresponding author. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, P.O.Box 124, 34000 Kragujevac, Serbia.Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Pharmacology, Institute of Biodesign and Complex System Modelling, First Moscow State Medical University I.M. Sechenov, Moscow, RussiaSpecial Hospital Merkur, Vrnjacka Banja, SerbiaClinic of Endocrinology, Military Medical Academy, Belgrade, SerbiaDepartment of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; Center of Excellence for Redox Balance Research in Cardiovascular and Metabolic Disorders; Kragujevac, Serbia; Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Moscow, Russia; Corresponding author. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, P.O.Box 124, 34000 Kragujevac, Serbia.Although scientific evidence has shown that natural mineral waters have potential beneficial metabolic effects, there is still very scarce data on their influence on type 2 diabetes mellitus (T2DM). The study was designed to investigate the effects of low mineral water from the “Sneznik-1/79″ source in Serbia on microbiota, metabolic, and oxidative stress parameters in patients with T2DM. In total, 60 patients with confirmed T2DM were included in the study, and they consumed “Sneznik-1/79″ water for 28 days. To examine the positive effects of “Sneznik-1/79″ water, we compared the results before and after the four weeks of “Sneznik-1/79″ water intake. Standard biochemical analyses were carried out, such as glucose level, lipid profile, and stool tests. The blood samples were collected to evaluate the effects of “Sneznik-1/79″ water on the redox status. At the end of the monitoring period, the total cholesterol concentration significantly dropped compared to the initial value. A significant improvement in intestinal peristalsis was observed, which was reflected in the fact that after four weeks, all patients established regular, daily bowel movements. Moreover, consumption of “Sneznik-1/79″ water eliminated the appearance of dysbiosis in 50% of patients. Additionally, the antioxidant capacity was improved by increasing the concentration of superoxide dismutase and reduced glutathione. The result of our study pointed out that the intake of “Sneznik-1/79″ water could be a promising adjuvant therapy for improving intestinal peristalsis as well as reducing the appearance of dysbiosis in T2DM patients.http://www.sciencedirect.com/science/article/pii/S2405844023059339Sneznik-1/79″ waterT2DMMicrobiotaOxidative stressLipid profile |
| spellingShingle | Nikola Jovicic Marijana Andjic Jovana Novakovic Nevena Jeremic Vladimir Zivkovic Ivan Srejovic Dejan Stanojevic Petar Ristic Sergey Bolevich Vladimir Jakovljevic The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus Heliyon Sneznik-1/79″ water T2DM Microbiota Oxidative stress Lipid profile |
| title | The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus |
| title_full | The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus |
| title_fullStr | The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus |
| title_full_unstemmed | The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus |
| title_short | The еffects of low mineral content water on microbiota, metabolic, and oxidative stress parameters in patients with type 2 diabetes mellitus |
| title_sort | еffects of low mineral content water on microbiota metabolic and oxidative stress parameters in patients with type 2 diabetes mellitus |
| topic | Sneznik-1/79″ water T2DM Microbiota Oxidative stress Lipid profile |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023059339 |
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