On the Possibility of Using Succinate in Hypoxia Developing in COVID-19
Aim. To provide a rationale for the feasibility of using the succinate-containing drugs to treat hypoxia associated with COVID-19 based on the analysis of experimental and clinical studies.Materials and methods. 84 Russian and international literature sources concerning the pathogenesis of COVID-19...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2021-07-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/2084 |
| _version_ | 1826562172525740032 |
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| author | Yu. P. Orlov N. V. Govorova O. V. Korpacheva V. V. Afanasyev I. A. Khilenko |
| author_facet | Yu. P. Orlov N. V. Govorova O. V. Korpacheva V. V. Afanasyev I. A. Khilenko |
| author_sort | Yu. P. Orlov |
| collection | DOAJ |
| description | Aim. To provide a rationale for the feasibility of using the succinate-containing drugs to treat hypoxia associated with COVID-19 based on the analysis of experimental and clinical studies.Materials and methods. 84 Russian and international literature sources concerning the pathogenesis of COVID-19 and the pathogenetic role of succinate in the management of COVID-19 associated hypoxia, oxidative stress and diaphragmatic dysfunction were analyzed. The literature search was performed using Pubmed and ELIBRARY.ru databases.Results. The literature analysis showed that tissue hypoxia, triggering the pathomorphological cascade of events and resulting in multiple organ failure is a central element of COVID-19 pathogenesis. Experimental and clinical studies show the positive impact of tissue hypoxia correction using succinate in both adult patients and children with various conditions associated with acute respiratory failure.Conclusion. The literature data provide a rationale for using succinate-containing drugs in the treatment of severe COVID-19. |
| first_indexed | 2024-04-10T01:27:11Z |
| format | Article |
| id | doaj.art-716e28ddbf624b59ab8f9556d299bb26 |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2025-03-14T09:43:51Z |
| publishDate | 2021-07-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-716e28ddbf624b59ab8f9556d299bb262025-03-02T11:29:38ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102021-07-01173789810.15360/1813-9779-2021-3-78-981798On the Possibility of Using Succinate in Hypoxia Developing in COVID-19Yu. P. Orlov0N. V. Govorova1O. V. Korpacheva2V. V. Afanasyev3I. A. Khilenko4Omsk State Medical University, Ministry of Health of RussiaOmsk State Medical University, Ministry of Health of RussiaOmsk State Medical University, Ministry of Health of RussiaI.I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaCity Clinical Hospital № 13Aim. To provide a rationale for the feasibility of using the succinate-containing drugs to treat hypoxia associated with COVID-19 based on the analysis of experimental and clinical studies.Materials and methods. 84 Russian and international literature sources concerning the pathogenesis of COVID-19 and the pathogenetic role of succinate in the management of COVID-19 associated hypoxia, oxidative stress and diaphragmatic dysfunction were analyzed. The literature search was performed using Pubmed and ELIBRARY.ru databases.Results. The literature analysis showed that tissue hypoxia, triggering the pathomorphological cascade of events and resulting in multiple organ failure is a central element of COVID-19 pathogenesis. Experimental and clinical studies show the positive impact of tissue hypoxia correction using succinate in both adult patients and children with various conditions associated with acute respiratory failure.Conclusion. The literature data provide a rationale for using succinate-containing drugs in the treatment of severe COVID-19.https://www.reanimatology.com/rmt/article/view/2084covid-19hypoxiaoxidative stressdiaphragmatic dysfunctionsuccinate conflict of interest. the authors declare no conflict of interest |
| spellingShingle | Yu. P. Orlov N. V. Govorova O. V. Korpacheva V. V. Afanasyev I. A. Khilenko On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 Общая реаниматология covid-19 hypoxia oxidative stress diaphragmatic dysfunction succinate conflict of interest. the authors declare no conflict of interest |
| title | On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 |
| title_full | On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 |
| title_fullStr | On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 |
| title_full_unstemmed | On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 |
| title_short | On the Possibility of Using Succinate in Hypoxia Developing in COVID-19 |
| title_sort | on the possibility of using succinate in hypoxia developing in covid 19 |
| topic | covid-19 hypoxia oxidative stress diaphragmatic dysfunction succinate conflict of interest. the authors declare no conflict of interest |
| url | https://www.reanimatology.com/rmt/article/view/2084 |
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