Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging
The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/6/1323 |
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| author | Gabriela Rapozo Guimarães Palloma Porto Almeida Leandro de Oliveira Santos Leane Perim Rodrigues Juliana Lott de Carvalho Mariana Boroni |
| author_facet | Gabriela Rapozo Guimarães Palloma Porto Almeida Leandro de Oliveira Santos Leane Perim Rodrigues Juliana Lott de Carvalho Mariana Boroni |
| author_sort | Gabriela Rapozo Guimarães |
| collection | DOAJ |
| description | The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer. In this review, we will highlight recent findings pertaining to the effects of aging hallmarks over Mφ, supporting the recognition of such cell types as a driving force in skin inflammaging and age-related diseases. We will also present recent research targeting Mφ as potential therapeutic interventions in inflammatory skin disorders and cancer. |
| first_indexed | 2024-03-10T11:01:30Z |
| format | Article |
| id | doaj.art-716f9ddeb55b4089933b0a14aa9fa034 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:01:30Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-716f9ddeb55b4089933b0a14aa9fa0342023-11-21T21:28:02ZengMDPI AGCells2073-44092021-05-01106132310.3390/cells10061323Hallmarks of Aging in Macrophages: Consequences to Skin InflammagingGabriela Rapozo Guimarães0Palloma Porto Almeida1Leandro de Oliveira Santos2Leane Perim Rodrigues3Juliana Lott de Carvalho4Mariana Boroni5Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231-050, BrazilLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231-050, BrazilLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231-050, BrazilGenomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasilia 70790-160, BrazilGenomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasilia 70790-160, BrazilLaboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231-050, BrazilThe skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer. In this review, we will highlight recent findings pertaining to the effects of aging hallmarks over Mφ, supporting the recognition of such cell types as a driving force in skin inflammaging and age-related diseases. We will also present recent research targeting Mφ as potential therapeutic interventions in inflammatory skin disorders and cancer.https://www.mdpi.com/2073-4409/10/6/1323immunosenescenceage-associated diseasesaging |
| spellingShingle | Gabriela Rapozo Guimarães Palloma Porto Almeida Leandro de Oliveira Santos Leane Perim Rodrigues Juliana Lott de Carvalho Mariana Boroni Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging Cells immunosenescence age-associated diseases aging |
| title | Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging |
| title_full | Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging |
| title_fullStr | Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging |
| title_full_unstemmed | Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging |
| title_short | Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging |
| title_sort | hallmarks of aging in macrophages consequences to skin inflammaging |
| topic | immunosenescence age-associated diseases aging |
| url | https://www.mdpi.com/2073-4409/10/6/1323 |
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