Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections
Like many pathogens inhabiting mucosal surfaces, nontypeable Haemophilus influenzae (NTHi) forms multicellular biofilm communities both in vitro and in various infection models. In the past 15 years much has been learned about determinants of biofilm formation by this organism and potential roles...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00097/full |
| _version_ | 1818933157080072192 |
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| author | W Edward Swords |
| author_facet | W Edward Swords |
| author_sort | W Edward Swords |
| collection | DOAJ |
| description | Like many pathogens inhabiting mucosal surfaces, nontypeable Haemophilus influenzae (NTHi) forms multicellular biofilm communities both in vitro and in various infection models. In the past 15 years much has been learned about determinants of biofilm formation by this organism and potential roles in bacterial virulence, especially in the context of chronic and recurrent infections. However, this concept has not been without some degree of controversy, and in the past some have expressed doubts about the relevance of NTHi biofilms to disease. In this review, I will summarize the present information on the composition and potential role(s) of NTHi biofilms in different clinical contexts, as well as highlight potential areas for future work. |
| first_indexed | 2024-12-20T04:43:55Z |
| format | Article |
| id | doaj.art-71701adadee74ceca0216a2cc5f6e5f3 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-20T04:43:55Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-71701adadee74ceca0216a2cc5f6e5f32022-12-21T19:53:03ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882012-07-01210.3389/fcimb.2012.0009727128Nontypeable Haemophilus influenzae biofilms: role in chronic airway infectionsW Edward Swords0Wake Forest School of MedicineLike many pathogens inhabiting mucosal surfaces, nontypeable Haemophilus influenzae (NTHi) forms multicellular biofilm communities both in vitro and in various infection models. In the past 15 years much has been learned about determinants of biofilm formation by this organism and potential roles in bacterial virulence, especially in the context of chronic and recurrent infections. However, this concept has not been without some degree of controversy, and in the past some have expressed doubts about the relevance of NTHi biofilms to disease. In this review, I will summarize the present information on the composition and potential role(s) of NTHi biofilms in different clinical contexts, as well as highlight potential areas for future work.http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00097/fullBiofilmsHaemophilus influenzaeOtitis Mediachronic obstructive pulmonary diseaserhinosinusitis |
| spellingShingle | W Edward Swords Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections Frontiers in Cellular and Infection Microbiology Biofilms Haemophilus influenzae Otitis Media chronic obstructive pulmonary disease rhinosinusitis |
| title | Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections |
| title_full | Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections |
| title_fullStr | Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections |
| title_full_unstemmed | Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections |
| title_short | Nontypeable Haemophilus influenzae biofilms: role in chronic airway infections |
| title_sort | nontypeable haemophilus influenzae biofilms role in chronic airway infections |
| topic | Biofilms Haemophilus influenzae Otitis Media chronic obstructive pulmonary disease rhinosinusitis |
| url | http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00097/full |
| work_keys_str_mv | AT wedwardswords nontypeablehaemophilusinfluenzaebiofilmsroleinchronicairwayinfections |