Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment
OBJECTIVES: To investigate pain intensity, interleukin-1β and prostaglandin E2 values in saliva during initial orthodontic treatment among varying age groups and their correlation between these mediators. MATERIALS AND METHODS: Twenty healthy patients distributed equally in age and gender groups wer...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Orthodontic Science |
| Subjects: | |
| Online Access: | http://www.jorthodsci.org/article.asp?issn=2278-0203;year=2019;volume=8;issue=1;spage=16;epage=16;aulast= |
| _version_ | 1817984933861261312 |
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| author | Amrit S Maan Anand K Patil |
| author_facet | Amrit S Maan Anand K Patil |
| author_sort | Amrit S Maan |
| collection | DOAJ |
| description | OBJECTIVES: To investigate pain intensity, interleukin-1β and prostaglandin E2 values in saliva during initial orthodontic treatment among varying age groups and their correlation between these mediators.
MATERIALS AND METHODS: Twenty healthy patients distributed equally in age and gender groups were chosen. Unstimulated saliva was collected before the placement of orthodontic fixed appliance (T0), 1 hour after the placement of the appliance with 0.014” nickel titanium archwire (T1), 1 month after the first visit (T2), and 1 hour after the placement of 0.016” nickel titanium archwire (T3). The saliva samples were then analyzed for prostaglandin E2 and interleukin-1β using enzyme-linked immunosorbent assay. Pain intensity was measured using a numerical rating scale.
RESULTS: Prostaglandin E2 and interleukin-1β levels had increased at T1 followed by a drop at T2 and a subsequent increase at T3. The prostaglandin E2 and interleukin-1β levels were higher in adults than children. There was an insignificant correlation between the interleukin-1β and prostaglandin E2 changes in all the patients. No significant differences were seen in pain scores between adults and children. Insignificant correlation was seen between pain scores and prostaglandin E2 and interleukin-1β.
CONCLUSION: Prostaglandin E2 and interleukin-1β can be detected in saliva and are increased in during the initial orthodontic treatment but are higher in adults than children. Pain intensity was not significantly different between adults and children. |
| first_indexed | 2024-04-13T23:50:48Z |
| format | Article |
| id | doaj.art-71706a82e15b4e9c9034be2c1d7eff86 |
| institution | Directory Open Access Journal |
| issn | 2278-0203 |
| language | English |
| last_indexed | 2024-04-13T23:50:48Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orthodontic Science |
| spelling | doaj.art-71706a82e15b4e9c9034be2c1d7eff862022-12-22T02:24:05ZengWolters Kluwer Medknow PublicationsJournal of Orthodontic Science2278-02032019-01-0181161610.4103/jos.JOS_13_19Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatmentAmrit S MaanAnand K PatilOBJECTIVES: To investigate pain intensity, interleukin-1β and prostaglandin E2 values in saliva during initial orthodontic treatment among varying age groups and their correlation between these mediators. MATERIALS AND METHODS: Twenty healthy patients distributed equally in age and gender groups were chosen. Unstimulated saliva was collected before the placement of orthodontic fixed appliance (T0), 1 hour after the placement of the appliance with 0.014” nickel titanium archwire (T1), 1 month after the first visit (T2), and 1 hour after the placement of 0.016” nickel titanium archwire (T3). The saliva samples were then analyzed for prostaglandin E2 and interleukin-1β using enzyme-linked immunosorbent assay. Pain intensity was measured using a numerical rating scale. RESULTS: Prostaglandin E2 and interleukin-1β levels had increased at T1 followed by a drop at T2 and a subsequent increase at T3. The prostaglandin E2 and interleukin-1β levels were higher in adults than children. There was an insignificant correlation between the interleukin-1β and prostaglandin E2 changes in all the patients. No significant differences were seen in pain scores between adults and children. Insignificant correlation was seen between pain scores and prostaglandin E2 and interleukin-1β. CONCLUSION: Prostaglandin E2 and interleukin-1β can be detected in saliva and are increased in during the initial orthodontic treatment but are higher in adults than children. Pain intensity was not significantly different between adults and children.http://www.jorthodsci.org/article.asp?issn=2278-0203;year=2019;volume=8;issue=1;spage=16;epage=16;aulast=adultschildreninitial orthodontic treatment interleukin-1βpainprostaglandin e2saliva |
| spellingShingle | Amrit S Maan Anand K Patil Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment Journal of Orthodontic Science adults children initial orthodontic treatment interleukin-1β pain prostaglandin e2 saliva |
| title | Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment |
| title_full | Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment |
| title_fullStr | Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment |
| title_full_unstemmed | Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment |
| title_short | Assessment of salivary interleukin-1β (IL-1β), prostaglandin E2(PGE2) levels and pain intensity in children and adults during initial orthodontic treatment |
| title_sort | assessment of salivary interleukin 1β il 1β prostaglandin e2 pge2 levels and pain intensity in children and adults during initial orthodontic treatment |
| topic | adults children initial orthodontic treatment interleukin-1β pain prostaglandin e2 saliva |
| url | http://www.jorthodsci.org/article.asp?issn=2278-0203;year=2019;volume=8;issue=1;spage=16;epage=16;aulast= |
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