Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study
Oxidative stress and sterile inflammation play roles in the induction and maintenance of metabolic syndrome (MetS). This study cohort included 170 females aged 40 to 45 years who were categorized according to the presentation of MetS components (e.g., central obesity, insulin resistance, atherogenic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/6/1221 |
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| author | Katarína Šebeková Marta Staruchová Csilla Mišľanová Aurélia Líšková Mira Horváthová Jana Tulinská Miroslava Lehotská Mikušová Michaela Szabová Radana Gurecká Ivana Koborová Melinda Csongová Tamás Tábi Éva Szökö Katarína Volkovová |
| author_facet | Katarína Šebeková Marta Staruchová Csilla Mišľanová Aurélia Líšková Mira Horváthová Jana Tulinská Miroslava Lehotská Mikušová Michaela Szabová Radana Gurecká Ivana Koborová Melinda Csongová Tamás Tábi Éva Szökö Katarína Volkovová |
| author_sort | Katarína Šebeková |
| collection | DOAJ |
| description | Oxidative stress and sterile inflammation play roles in the induction and maintenance of metabolic syndrome (MetS). This study cohort included 170 females aged 40 to 45 years who were categorized according to the presentation of MetS components (e.g., central obesity, insulin resistance, atherogenic dyslipidemia, and elevated systolic blood pressure) as controls not presenting a single component (n = 43), those with pre-MetS displaying one to two components (n = 70), and females manifesting MetS, e.g., ≥3 components (n = 53). We analyzed the trends of seventeen oxidative and nine inflammatory status markers across three clinical categories. A multivariate regression of selected oxidative status and inflammatory markers on the components of MetS was performed. Markers of oxidative damage (malondialdehyde and advanced-glycation-end-products-associated fluorescence of plasma) were similar across the groups. Healthy controls displayed lower uricemia and higher bilirubinemia than females with MetS; and lower leukocyte counts, concentrations of C-reactive protein, interleukine-6, and higher levels of carotenoids/lipids and soluble receptors for advanced glycation end-products than those with pre-MetS and MetS. In multivariate regression models, levels of C-reactive protein, uric acid, and interleukine-6 were consistently associated with MetS components, although the impacts of single markers differed. Our data suggest that a proinflammatory imbalance precedes the manifestation of MetS, while an imbalance of oxidative status accompanies overt MetS. Further studies are needed to elucidate whether determining markers beyond traditional ones could help improve the prognosis of subjects at an early stage of MetS. |
| first_indexed | 2024-03-11T02:49:45Z |
| format | Article |
| id | doaj.art-71706ac7008d4cf9bf8e644f064f9940 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T02:49:45Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-71706ac7008d4cf9bf8e644f064f99402023-11-18T09:03:09ZengMDPI AGAntioxidants2076-39212023-06-01126122110.3390/antiox12061221Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional StudyKatarína Šebeková0Marta Staruchová1Csilla Mišľanová2Aurélia Líšková3Mira Horváthová4Jana Tulinská5Miroslava Lehotská Mikušová6Michaela Szabová7Radana Gurecká8Ivana Koborová9Melinda Csongová10Tamás Tábi11Éva Szökö12Katarína Volkovová13Institute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava, 83303 Bratislava, SlovakiaInstitute of Biology, Medical Faculty, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaInstitute of Nutrition, Faculty of Nursing and Medical Professional Studies, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Immunology and Immunotoxicology, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Immunology and Immunotoxicology, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Immunology and Immunotoxicology, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Immunology and Immunotoxicology, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Immunology and Immunotoxicology, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava, 83303 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava, 83303 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava, 83303 Bratislava, SlovakiaDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, 1085 Budapest, HungaryDepartment of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, 1085 Budapest, HungaryInstitute of Biology, Medical Faculty, Slovak Medical University in Bratislava, 83303 Bratislava, SlovakiaOxidative stress and sterile inflammation play roles in the induction and maintenance of metabolic syndrome (MetS). This study cohort included 170 females aged 40 to 45 years who were categorized according to the presentation of MetS components (e.g., central obesity, insulin resistance, atherogenic dyslipidemia, and elevated systolic blood pressure) as controls not presenting a single component (n = 43), those with pre-MetS displaying one to two components (n = 70), and females manifesting MetS, e.g., ≥3 components (n = 53). We analyzed the trends of seventeen oxidative and nine inflammatory status markers across three clinical categories. A multivariate regression of selected oxidative status and inflammatory markers on the components of MetS was performed. Markers of oxidative damage (malondialdehyde and advanced-glycation-end-products-associated fluorescence of plasma) were similar across the groups. Healthy controls displayed lower uricemia and higher bilirubinemia than females with MetS; and lower leukocyte counts, concentrations of C-reactive protein, interleukine-6, and higher levels of carotenoids/lipids and soluble receptors for advanced glycation end-products than those with pre-MetS and MetS. In multivariate regression models, levels of C-reactive protein, uric acid, and interleukine-6 were consistently associated with MetS components, although the impacts of single markers differed. Our data suggest that a proinflammatory imbalance precedes the manifestation of MetS, while an imbalance of oxidative status accompanies overt MetS. Further studies are needed to elucidate whether determining markers beyond traditional ones could help improve the prognosis of subjects at an early stage of MetS.https://www.mdpi.com/2076-3921/12/6/1221cardiometabolic risk markersuric acidbilirubinantioxidative enzymessRAGEcellular adhesion molecules |
| spellingShingle | Katarína Šebeková Marta Staruchová Csilla Mišľanová Aurélia Líšková Mira Horváthová Jana Tulinská Miroslava Lehotská Mikušová Michaela Szabová Radana Gurecká Ivana Koborová Melinda Csongová Tamás Tábi Éva Szökö Katarína Volkovová Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study Antioxidants cardiometabolic risk markers uric acid bilirubin antioxidative enzymes sRAGE cellular adhesion molecules |
| title | Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study |
| title_full | Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study |
| title_fullStr | Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study |
| title_full_unstemmed | Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study |
| title_short | Association of Inflammatory and Oxidative Status Markers with Metabolic Syndrome and Its Components in 40-to-45-Year-Old Females: A Cross-Sectional Study |
| title_sort | association of inflammatory and oxidative status markers with metabolic syndrome and its components in 40 to 45 year old females a cross sectional study |
| topic | cardiometabolic risk markers uric acid bilirubin antioxidative enzymes sRAGE cellular adhesion molecules |
| url | https://www.mdpi.com/2076-3921/12/6/1221 |
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