Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis
Abstract Background The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. Methods Using appropriate keywords, we identified relevant studies using PubMed,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Medical Genetics |
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| Online Access: | https://doi.org/10.1186/s12881-020-0952-2 |
| _version_ | 1819075430695567360 |
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| author | Rui Huang Su-Rui Zhao Ya Li Fang Liu Yue Gong Jun Xing Ze-Sheng Xu |
| author_facet | Rui Huang Su-Rui Zhao Ya Li Fang Liu Yue Gong Jun Xing Ze-Sheng Xu |
| author_sort | Rui Huang |
| collection | DOAJ |
| description | Abstract Background The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. Methods Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on eligible studies, we performed a meta-analysis of association between 308G/A, 238G/A, 857C/T, 863C/A and 1031 T/C polymorphisms in TNF-α and risk of CAD. Results We found 25 studies that were consistent with this meta-analysis, including 7697 patients in the CAD group and 9655 control patients. TNF-α 308G/A locus A showed no significant association with CAD susceptibility by the five models in the analysis of the overall population, European, African, South Asian, and North Asian patients. TNF-α 863C/A locus A and 1031 T/C locus C exhibited no significant association with CAD susceptibility. TNF-α 238G/A locus A had no significant association with CAD susceptibility in the overall population. However, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans and north Asians. TNF-α 857C/T locus T had no significant association with CAD susceptibility in the analysis of the overall population and Europeans. In the north Asian population, TNF-α 857C/T locus T was associated with lower CAD susceptibility by the heterozygote model. Conclusion TNF-α 308G/A, 857C/T, 863C/A, and 1031 T/C has no significant association with CAD susceptibility. TNF-α 238G/A locus A has significant association with CAD susceptibility in Europeans and north Asians, but has no significant association in the overall population. Studies with a larger sample size are required to confirm the association between TNF-α 238G/A and CAD susceptibility. |
| first_indexed | 2024-12-21T18:25:17Z |
| format | Article |
| id | doaj.art-71710c2a5056437c854789cb358609d6 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-21T18:25:17Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-71710c2a5056437c854789cb358609d62022-12-21T18:54:25ZengBMCBMC Medical Genetics1471-23502020-02-0121111510.1186/s12881-020-0952-2Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysisRui Huang0Su-Rui Zhao1Ya Li2Fang Liu3Yue Gong4Jun Xing5Ze-Sheng Xu6Department of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalDepartment of Cardiology, Cangzhou Central HospitalAbstract Background The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. Methods Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on eligible studies, we performed a meta-analysis of association between 308G/A, 238G/A, 857C/T, 863C/A and 1031 T/C polymorphisms in TNF-α and risk of CAD. Results We found 25 studies that were consistent with this meta-analysis, including 7697 patients in the CAD group and 9655 control patients. TNF-α 308G/A locus A showed no significant association with CAD susceptibility by the five models in the analysis of the overall population, European, African, South Asian, and North Asian patients. TNF-α 863C/A locus A and 1031 T/C locus C exhibited no significant association with CAD susceptibility. TNF-α 238G/A locus A had no significant association with CAD susceptibility in the overall population. However, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans and north Asians. TNF-α 857C/T locus T had no significant association with CAD susceptibility in the analysis of the overall population and Europeans. In the north Asian population, TNF-α 857C/T locus T was associated with lower CAD susceptibility by the heterozygote model. Conclusion TNF-α 308G/A, 857C/T, 863C/A, and 1031 T/C has no significant association with CAD susceptibility. TNF-α 238G/A locus A has significant association with CAD susceptibility in Europeans and north Asians, but has no significant association in the overall population. Studies with a larger sample size are required to confirm the association between TNF-α 238G/A and CAD susceptibility.https://doi.org/10.1186/s12881-020-0952-2Tumor necrosis factor-αGene polymorphismsCoronary artery diseaseMeta-analysis |
| spellingShingle | Rui Huang Su-Rui Zhao Ya Li Fang Liu Yue Gong Jun Xing Ze-Sheng Xu Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis BMC Medical Genetics Tumor necrosis factor-α Gene polymorphisms Coronary artery disease Meta-analysis |
| title | Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis |
| title_full | Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis |
| title_fullStr | Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis |
| title_full_unstemmed | Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis |
| title_short | Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis |
| title_sort | association of tumor necrosis factor α gene polymorphisms and coronary artery disease susceptibility a systematic review and meta analysis |
| topic | Tumor necrosis factor-α Gene polymorphisms Coronary artery disease Meta-analysis |
| url | https://doi.org/10.1186/s12881-020-0952-2 |
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