Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads
Exposure to perfluoroalkyl substances (PFASs) is of public concern due to their persistent exposure and adverse health effects. Placental transfer of PFASs is an important excretion pathway of these chemicals in pregnant women and exposure route in fetuses. We measured PFAS concentrations in materna...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/9/7/168 |
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| author | Habyeong Kang Hee-Sun Kim Yeong Sook Yoon Jeongsun Lee Younglim Kho Jisun Lee Hye Jin Chang Yoon Hee Cho Young Ah Kim |
| author_facet | Habyeong Kang Hee-Sun Kim Yeong Sook Yoon Jeongsun Lee Younglim Kho Jisun Lee Hye Jin Chang Yoon Hee Cho Young Ah Kim |
| author_sort | Habyeong Kang |
| collection | DOAJ |
| description | Exposure to perfluoroalkyl substances (PFASs) is of public concern due to their persistent exposure and adverse health effects. Placental transfer of PFASs is an important excretion pathway of these chemicals in pregnant women and exposure route in fetuses. We measured PFAS concentrations in maternal, paternal, and umbilical cord serum collected from 62 pregnant Korean women and matched biological fathers of the fetuses. Placental transfer rates (cord to maternal serum ratio) of PFASs were also calculated. Demographics and pregnancy-related factors determining the placental transfer rates were identified using linear regression models. Maternal, paternal, and cord serum showed different PFASs compositions. Among the PFASs, perfluorooctane sulfonate (PFOS) showed the highest concentrations in maternal and paternal serum, while perfluorooctanoic acid (PFOA) showed the highest concentration in cord serum. There was a higher proportion of perfluoroalkyl carboxylic acids (PFCAs) with 9–12 carbon chains than those with 13–14 carbon chains in maternal and paternal serum, but this proportion was in the opposite direction in cord serum. PFOA and perfluorohexane sulfonate (PFHxS) had higher placental transfer rates (means of 0.32 and 0.36, respectively) than PFOS (mean of 0.12), which is in line with the results of previous studies. Gestational age and birth weight were positively associated with placental transfer rate of PFOA, PFHxS, and PFOS, while pre-pregnant BMI and weight were inversely associated with PFOS. This study showed that placental transfer of PFASs differs by compounds and is associated with pregnancy-related factors. Further studies on novel PFASs are warranted for Korean pregnant women. |
| first_indexed | 2024-03-10T09:20:50Z |
| format | Article |
| id | doaj.art-71724f0ea492401a9a13141b959dc4a6 |
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| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T09:20:50Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-71724f0ea492401a9a13141b959dc4a62023-11-22T05:10:37ZengMDPI AGToxics2305-63042021-07-019716810.3390/toxics9070168Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant TriadsHabyeong Kang0Hee-Sun Kim1Yeong Sook Yoon2Jeongsun Lee3Younglim Kho4Jisun Lee5Hye Jin Chang6Yoon Hee Cho7Young Ah Kim8Department of Environmental Health Sciences, School of Public Health, Seoul National University, Seoul 08826, KoreaDepartments of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang-si 10326, KoreaCenter for Health Promotion, Departments of Family Medicine, Inje University Ilsan Paik Hospital, Goyang-si 10380, KoreaDepartment of Health, Environment and Safety, School of Human & Environmental Service, Eulji University, Seongnam-si 13135, KoreaDepartment of Health, Environment and Safety, School of Human & Environmental Service, Eulji University, Seongnam-si 13135, KoreaDepartment of Obstetrics and Gynecology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu 41944, KoreaDepartment of Obstetrics and Gynecology, Ajou University Hospital, Ajou University School of Medicine, Suwon-si 16499, KoreaDepartment of Biomedical and Pharmaceutical Sciences, The University of Montana, Missoula, MT 59812, USADepartments of Obstetrics and Gynecology, Inje University, Ilsan Paik Hospital, Goyang-si 10380, KoreaExposure to perfluoroalkyl substances (PFASs) is of public concern due to their persistent exposure and adverse health effects. Placental transfer of PFASs is an important excretion pathway of these chemicals in pregnant women and exposure route in fetuses. We measured PFAS concentrations in maternal, paternal, and umbilical cord serum collected from 62 pregnant Korean women and matched biological fathers of the fetuses. Placental transfer rates (cord to maternal serum ratio) of PFASs were also calculated. Demographics and pregnancy-related factors determining the placental transfer rates were identified using linear regression models. Maternal, paternal, and cord serum showed different PFASs compositions. Among the PFASs, perfluorooctane sulfonate (PFOS) showed the highest concentrations in maternal and paternal serum, while perfluorooctanoic acid (PFOA) showed the highest concentration in cord serum. There was a higher proportion of perfluoroalkyl carboxylic acids (PFCAs) with 9–12 carbon chains than those with 13–14 carbon chains in maternal and paternal serum, but this proportion was in the opposite direction in cord serum. PFOA and perfluorohexane sulfonate (PFHxS) had higher placental transfer rates (means of 0.32 and 0.36, respectively) than PFOS (mean of 0.12), which is in line with the results of previous studies. Gestational age and birth weight were positively associated with placental transfer rate of PFOA, PFHxS, and PFOS, while pre-pregnant BMI and weight were inversely associated with PFOS. This study showed that placental transfer of PFASs differs by compounds and is associated with pregnancy-related factors. Further studies on novel PFASs are warranted for Korean pregnant women.https://www.mdpi.com/2305-6304/9/7/168perfluoroalkyl acidscord bloodplacentapregnancyprenatal exposure |
| spellingShingle | Habyeong Kang Hee-Sun Kim Yeong Sook Yoon Jeongsun Lee Younglim Kho Jisun Lee Hye Jin Chang Yoon Hee Cho Young Ah Kim Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads Toxics perfluoroalkyl acids cord blood placenta pregnancy prenatal exposure |
| title | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads |
| title_full | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads |
| title_fullStr | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads |
| title_full_unstemmed | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads |
| title_short | Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads |
| title_sort | placental transfer and composition of perfluoroalkyl substances pfass a korean birth panel of parent infant triads |
| topic | perfluoroalkyl acids cord blood placenta pregnancy prenatal exposure |
| url | https://www.mdpi.com/2305-6304/9/7/168 |
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