Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes
Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/20/23/5827 |
| _version_ | 1811310560020529152 |
|---|---|
| author | Olof Eriksson Ram Kumar Selvaraju Marie Berglund Daniel Espes |
| author_facet | Olof Eriksson Ram Kumar Selvaraju Marie Berglund Daniel Espes |
| author_sort | Olof Eriksson |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However, the presence and activity of BAT in T1D have not been studied, despite the fact that preclinical studies have shown that transplantation of BAT in mouse models of T1D can restore metabolic control. The metabolic activity of BAT, white adipose tissue (WAT), and skeletal muscle was investigated in patients with T1D (<i>n</i> = 11) by 2-deoxy-2-(<sup>18</sup>F)fluoro-D-glucose PET/CT after cold stimulation. Functional BAT was detected in 4 out of 11 individuals with T1D with a prevalence of 36%. The glucose utilization rate in the supraclavicular BAT regions ranged from 0.75−38.7 µmol × min<sup>−1</sup> × 100 g<sup>−1</sup>. The glucose utilization per gram tissue was higher in BAT when compared with both WAT (<i>p</i> = 0.049) and skeletal muscle (<i>p</i> = 0.039). However, no correlation between BAT activity and metabolic control or insulin requirements was found. In conclusion, for the first time, cold-induced BAT was detected in patients with T1D with a wide range in metabolic activity. Contrary to findings in animal models, the metabolic activity of BAT had negligible impact on insulin requirements or metabolic control in T1D under normal physiological conditions. |
| first_indexed | 2024-04-13T10:00:51Z |
| format | Article |
| id | doaj.art-717394d67ec1470c8ec5a3b477c835cc |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T10:00:51Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-717394d67ec1470c8ec5a3b477c835cc2022-12-22T02:51:14ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-11-012023582710.3390/ijms20235827ijms20235827Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 DiabetesOlof Eriksson0Ram Kumar Selvaraju1Marie Berglund2Daniel Espes3Science for Life Laboratory, Department of Medicinal Chemistry, Division of Molecular Imaging, Uppsala University, 75123 Uppsala, SwedenScience for Life Laboratory, Department of Medicinal Chemistry, Division of Molecular Imaging, Uppsala University, 75123 Uppsala, SwedenDepartment of Public Health and Caring Sciences, Uppsala University, 75237 Uppsala, SwedenDepartment of Medical Sciences, Uppsala University, 75185 Uppsala, SwedenType 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However, the presence and activity of BAT in T1D have not been studied, despite the fact that preclinical studies have shown that transplantation of BAT in mouse models of T1D can restore metabolic control. The metabolic activity of BAT, white adipose tissue (WAT), and skeletal muscle was investigated in patients with T1D (<i>n</i> = 11) by 2-deoxy-2-(<sup>18</sup>F)fluoro-D-glucose PET/CT after cold stimulation. Functional BAT was detected in 4 out of 11 individuals with T1D with a prevalence of 36%. The glucose utilization rate in the supraclavicular BAT regions ranged from 0.75−38.7 µmol × min<sup>−1</sup> × 100 g<sup>−1</sup>. The glucose utilization per gram tissue was higher in BAT when compared with both WAT (<i>p</i> = 0.049) and skeletal muscle (<i>p</i> = 0.039). However, no correlation between BAT activity and metabolic control or insulin requirements was found. In conclusion, for the first time, cold-induced BAT was detected in patients with T1D with a wide range in metabolic activity. Contrary to findings in animal models, the metabolic activity of BAT had negligible impact on insulin requirements or metabolic control in T1D under normal physiological conditions.https://www.mdpi.com/1422-0067/20/23/5827type 1 diabetesbrown adipose tissuepositron emission tomographymetabolic control |
| spellingShingle | Olof Eriksson Ram Kumar Selvaraju Marie Berglund Daniel Espes Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes International Journal of Molecular Sciences type 1 diabetes brown adipose tissue positron emission tomography metabolic control |
| title | Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes |
| title_full | Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes |
| title_fullStr | Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes |
| title_full_unstemmed | Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes |
| title_short | Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes |
| title_sort | metabolically active brown adipose tissue is found in adult subjects with type 1 diabetes |
| topic | type 1 diabetes brown adipose tissue positron emission tomography metabolic control |
| url | https://www.mdpi.com/1422-0067/20/23/5827 |
| work_keys_str_mv | AT oloferiksson metabolicallyactivebrownadiposetissueisfoundinadultsubjectswithtype1diabetes AT ramkumarselvaraju metabolicallyactivebrownadiposetissueisfoundinadultsubjectswithtype1diabetes AT marieberglund metabolicallyactivebrownadiposetissueisfoundinadultsubjectswithtype1diabetes AT danielespes metabolicallyactivebrownadiposetissueisfoundinadultsubjectswithtype1diabetes |