Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death

Lung inflammation and interstitial fibrosis by targeted alveolar epithelial type I cell death

IntroductionThe pathogenesis of chronic lung diseases is multifaceted with a major role of recurrent micro-injuries of the epithelium. While several reports clearly indicated a prominent role for surfactant-producing alveolar epithelial type 2 (AT2) cells, the contribution of gas exchange-permissive...

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Bibliographic Details
Main Authors: Sandra Carignon, Dorian De Moura Rodrigues, David Gosset, Elodie Culerier, Sarah Huot-Marchand, Florence Savigny, Eric Kaya, Valerie Quesniaux, Aurélie Gombault, Isabelle Couillin, Bernhard Ryffel, Marc Le Bert, Nicolas Riteau
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
AT1 cell depletion
sterile inflammation
lung injury
iDTR
cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1261483/full

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