Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation
Purpose: The main objective of the current research work was to formulate and evaluate furosemide loaded silica lipid hybrid microparticles for improved oral delivery. A novel silica-lipid hybrid microparticulate system is used for enhancing the oral absorption of low solubility and low permeability...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tabriz University of Medical Sciences
2015-09-01
|
| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-403.pdf |
| _version_ | 1818789702087475200 |
|---|---|
| author | Swapna Sambaraj Divya Ammula Vijaykumar Nagabandi |
| author_facet | Swapna Sambaraj Divya Ammula Vijaykumar Nagabandi |
| author_sort | Swapna Sambaraj |
| collection | DOAJ |
| description | Purpose: The main objective of the current research work was to
formulate and evaluate furosemide loaded silica lipid hybrid microparticles for
improved oral delivery. A novel silica-lipid hybrid microparticulate system is
used for enhancing the oral absorption of low solubility and low permeability
of (BCS Class IV) drugs. Silica-lipid hybrid microparticles include the drug
solubilising effect of dispersed lipids and stabilizing effect of hydrophilic
silica particles to increase drug solubilisation, which leads to enhanced oral
bioavailability.
Methods: The slica lipid hybrid (SLH) microparticles were composed
of poorly soluble drug (furosemide), dispersion of oil phase (Soya bean oil and
miglyol) in lecithin (Phospholipoid 90H), non-ionic surfactant (Polysorbate 80)
and adsorbent (Aerosol 380). Saturation solubility studies were performed in
different oils and surfactants with increased concentration of drug revealed
increased solubility of furosemide.
Results: In vitro dissolution studies
conducted under simulated gastric medium revealed 2-4 fold increase in
dissolution efficiencies for SLH microparticles compared to that of pure drug
(furosemide) and marketed formulation Lasix®. Ex vivo studies showed
enhanced lipid digestibility, which improved drug permeability. Solid-state
characterization of SLH microparticles by X-ray powder diffraction and Fourier
transform infrared spectroscopic analysis confirmed non-crystalline nature and
more compatibility of furosemide in silica-lipid hybrid microparticles.
Conclusion: It can be concluded that the
role of lipids and hydrophilic silica based carrier highlighted in enhancing
solubility and permeability, and hence the oral bioavailability of poorly
soluble drugs. |
| first_indexed | 2024-12-18T14:43:45Z |
| format | Article |
| id | doaj.art-7175e12be4194319acaaa212403c4ede |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-12-18T14:43:45Z |
| publishDate | 2015-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-7175e12be4194319acaaa212403c4ede2022-12-21T21:04:20ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082015-09-015340340910.15171/apb.2015.055APB_2595_20150103133942Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo EvaluationSwapna Sambaraj0Divya Ammula1Vijaykumar Nagabandi2Department of Industrial Pharmacy, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal, Telangana State, India.Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal, Telangana State, India.Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal, Telangana State, India.Purpose: The main objective of the current research work was to formulate and evaluate furosemide loaded silica lipid hybrid microparticles for improved oral delivery. A novel silica-lipid hybrid microparticulate system is used for enhancing the oral absorption of low solubility and low permeability of (BCS Class IV) drugs. Silica-lipid hybrid microparticles include the drug solubilising effect of dispersed lipids and stabilizing effect of hydrophilic silica particles to increase drug solubilisation, which leads to enhanced oral bioavailability. Methods: The slica lipid hybrid (SLH) microparticles were composed of poorly soluble drug (furosemide), dispersion of oil phase (Soya bean oil and miglyol) in lecithin (Phospholipoid 90H), non-ionic surfactant (Polysorbate 80) and adsorbent (Aerosol 380). Saturation solubility studies were performed in different oils and surfactants with increased concentration of drug revealed increased solubility of furosemide. Results: In vitro dissolution studies conducted under simulated gastric medium revealed 2-4 fold increase in dissolution efficiencies for SLH microparticles compared to that of pure drug (furosemide) and marketed formulation Lasix®. Ex vivo studies showed enhanced lipid digestibility, which improved drug permeability. Solid-state characterization of SLH microparticles by X-ray powder diffraction and Fourier transform infrared spectroscopic analysis confirmed non-crystalline nature and more compatibility of furosemide in silica-lipid hybrid microparticles. Conclusion: It can be concluded that the role of lipids and hydrophilic silica based carrier highlighted in enhancing solubility and permeability, and hence the oral bioavailability of poorly soluble drugs.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-403.pdfSilica lipid hybridMicroparticlesEntrapment efficiencyDissolutionPermeation |
| spellingShingle | Swapna Sambaraj Divya Ammula Vijaykumar Nagabandi Furosemide Loaded Silica-Lipid Hybrid Microparticles: Formulation Development, in vitro and ex vivo Evaluation Advanced Pharmaceutical Bulletin Silica lipid hybrid Microparticles Entrapment efficiency Dissolution Permeation |
| title | Furosemide Loaded Silica-Lipid Hybrid
Microparticles: Formulation Development, in vitro and ex vivo
Evaluation |
| title_full | Furosemide Loaded Silica-Lipid Hybrid
Microparticles: Formulation Development, in vitro and ex vivo
Evaluation |
| title_fullStr | Furosemide Loaded Silica-Lipid Hybrid
Microparticles: Formulation Development, in vitro and ex vivo
Evaluation |
| title_full_unstemmed | Furosemide Loaded Silica-Lipid Hybrid
Microparticles: Formulation Development, in vitro and ex vivo
Evaluation |
| title_short | Furosemide Loaded Silica-Lipid Hybrid
Microparticles: Formulation Development, in vitro and ex vivo
Evaluation |
| title_sort | furosemide loaded silica lipid hybrid microparticles formulation development in vitro and ex vivo evaluation |
| topic | Silica lipid hybrid Microparticles Entrapment efficiency Dissolution Permeation |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-5-403.pdf |
| work_keys_str_mv | AT swapnasambaraj furosemideloadedsilicalipidhybridmicroparticlesformulationdevelopmentinvitroandexvivoevaluation AT divyaammula furosemideloadedsilicalipidhybridmicroparticlesformulationdevelopmentinvitroandexvivoevaluation AT vijaykumarnagabandi furosemideloadedsilicalipidhybridmicroparticlesformulationdevelopmentinvitroandexvivoevaluation |