Brolucizumab in age-related macular neovascularization (BRAIN study): Efficacy, optical coherence tomography biomarkers, and safety profile

Background: Brolucizumab is a new anti-vascular endothelial growth factor (anti-VEGF) in the treatment of neovascular age-related macular degeneration (nAMD) and idiopathic polypoidal choroidal vasculopathy (IPCV). Materials and Methods: A retrospective, consecutive, interventional study was conduct...

Full description

Bibliographic Details
Main Authors:	Supriya Dabir, Arthi Mohankumar, Manoj G Khatri, Mohan Rajan
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2024-01-01
Series:	Indian Journal of Ophthalmology
Subjects:	age-related macular degeneration anti-vascular endothelial growth factor brolucizumab choroidal neovascular membrane idiopathic polypoidal choroidal vasculopathy intraretinal fluid pigment epithelial detachment subretinal fluid subretinal hyperreflective membrane
Online Access:	http://www.ijo.in/article.asp?issn=0301-4738;year=2024;volume=72;issue=13;spage=33;epage=36;aulast=Dabir

Similar Items

Efficacy of a single injection of brolucizumab in neovascular age-related macular degeneration on visual acuity and micromorphometry
by: Shrinivas Joshi, et al.
Published: (2023-01-01)

Intravitreal aflibercept treatment in eyes with exudative age-related macular degeneration following prior treatment with intravitreal ranibizumab
by: Daniel Sanju Narayan, et al.
Published: (2015-01-01)

Hyperreflective material in patients with non-neovascular pachychoroid disease
by: Maiko Maruyama-Inoue, et al.
Published: (2023-06-01)

Evaluating photodynamic therapy versus brolucizumab as a second-line treatment for polypoidal choroidal vasculopathy
by: Ryoh Funatsu, et al.
Published: (2024-04-01)

Initial experience in treating polypoidal choroidal vasculopathy with brolucizumab in Indian eyes – A multicenter retrospective study
by: DebdulalChakraborty, et al.
Published: (2022-01-01)

The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration
by: Yousif Subhi, et al.
Published: (2019-08-01)

Management of Submacular Hemorrhage Using Intravitreal Brolucizumab with Pneumatic Displacement: A Case Series
by: Somnath Chakraborty, et al.
Published: (2022-11-01)

Progressive Massive Choroidal Neovascularization, an Aggressive Phenotype: Case Report
by: Renata García-Franco, et al.
Published: (2022-06-01)

Comparison of Outcomes between 3 Monthly Brolucizumab and Aflibercept Injections for Polypoidal Choroidal Vasculopathy
by: Yoshiko Fukuda, et al.
Published: (2021-09-01)

Response to brolucizumab treatment for refractory serous pigment epithelial detachment secondary to polypoidal choroidal vasculopathy
by: Seung Wan Nam, et al.
Published: (2022-12-01)

Iatrogenic choroidal neovascularization associated with subretinal gene therapy surgery
by: Kenneth W. Price, et al.
Published: (2022-09-01)

Antivascular endothelial growth factor in treatment of choroidal osteoma not associated with choroidal neovascular membrane
by: Thomas Cherian, et al.
Published: (2017-01-01)

A Treat-and-Extend Regimen of Intravitreal Brolucizumab for Exudative Age-Related Macular Degeneration Refractory to Aflibercept: A 12-Month Result
by: Wataru Kikushima, et al.
Published: (2023-04-01)

Neovascular Remodeling and Subretinal Fibrosis as Biomarkers for Predicting Incomplete Response to Anti-VEGF Therapy in Neovascular Age-Related Macular Degeneration
by: Jing Wu, et al.
Published: (2022-04-01)

Short-Term Effects of Brolucizumab in the Treatment of Wet Age-Related Macular Degeneration or Polypoidal Choroidopathy Refractory to Previous Anti-Vascular Endothelial Growth Factor Therapy
by: Alan Y. Hsu, et al.
Published: (2022-11-01)

A Systematic Prospective Comparison of Fluid Volume Evaluation across OCT Devices Used in Clinical Practice
by: Klaudia Kostolna, MD, et al.
Published: (2024-05-01)

Different Morphology of Branching Neovascular Network in Polypoidal Choroidal Vasculopathy: A Swept-Source Optical Coherence Tomography Angiography Study
by: Lulu Chen, et al.
Published: (2023-01-01)

A case of intraocular inflammation after intravitreal brolucizumab injection monitored by laser flare-cell photometer
by: Masaaki Saito, et al.
Published: (2022-12-01)

Case Series on Initial Responses to Intravitreal Brolucizumab in Patients with Recalcitrant Chronic Wet Age-Related Macular Degeneration
by: Avaylon J, et al.
Published: (2020-05-01)

Pachychoroid neovasculopathy in extramacular choroidal neovascularization
by: Gupta MP, et al.
Published: (2016-07-01)

Persistent macular detachment after successful macular hole closure and its management in an emmetropic eye
by: C K Nagesha, et al.
Published: (2020-01-01)

Association between inflammatory cytokines in the aqueous humor and hyperreflective foci on optical coherence tomography in patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
by: Jianbo Mao, et al.
Published: (2022-09-01)

Real-World Effectiveness, Treatment Pattern, and Safety of Ranibizumab in Korean Patients with Neovascular Age-Related Macular Degeneration: Subgroup Analyses from the LUMINOUS Study
by: Sagong M, et al.
Published: (2021-05-01)

Chorioretinal coloboma complications: retinal detachment and choroidal neovascular membrane
by: Rehan M Hussain, et al.
Published: (2017-01-01)

Quantitative effect of subretinal fluid and intraretinal edema on visual acuity in uveitic cystoid macular edema
by: Eric W. Weldy, et al.
Published: (2021-10-01)

Long-Term Follow-Up of Polypoidal Choroidal Vasculopathy Secondary to Angioid Streaks Treated by Intravitreal Aflibercept and Ranibizumab
by: James G. Wong, et al.
Published: (2017-04-01)

Investigation of the Trend of Selecting Anti-Vascular Endothelial Growth Factor Agents for the Initial Treatment of Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
by: Jae-Hui Kim, et al.
Published: (2021-08-01)

One-year outcome of intravitreal aflibercept injection for age-related macular degeneration resistant to ranibizumab: rapid morphologic recovery and subsequent visual improvement
by: Hirakata T, et al.
Published: (2016-05-01)

Factors for Visual Acuity Improvement After Anti-VEGF Treatment of Wet Age-Related Macular Degeneration in China: 12 Months Follow up
by: Yan Lu, et al.
Published: (2021-11-01)

Effect of Epiretinal Membrane Peeling on Intravitreal Aflibercept Therapy Response for Polypoidal Choroidal Vasculopathy: A Case Report
by: Aslı Kırmacı, et al.
Published: (2018-04-01)

Posterior choroidal effusion following uneventful cataract surgery
by: B Koshal Ram, et al.
Published: (2022-01-01)

Optical coherence tomography characteristics of responses to intravitreal bevacizumab in idiopathic choroidal neovascularization
by: Syed Nasir Ali Shah, et al.
Published: (2016-02-01)

Metabolomics study of treatment response to conbercept of patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
by: Yinchen Shen, et al.
Published: (2022-09-01)

Prevalence of Polypoidal Choroidal Vasculopathy in Eyes with Neovascular Age-Related Macular Degeneration Resistant to Intravitreal Anti-VEGF Treatment
by: Jale Menteş, et al.
Published: (2022-10-01)

Circumscribed choroidal hemangioma
by: Saeed Karimi, et al.
Published: (2015-01-01)

Serum Amyloid A 4 as a Common Marker of Persistent Inflammation in Patients with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy
by: Liu Q, et al.
Published: (2023-08-01)

Polypoidal Choroidal Vasculopathy after Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration: A Case Report with Long-Term Follow-Up
by: Alexandra Steinemann, et al.
Published: (2021-04-01)

Differentially Regulated Apolipoproteins and Lipid Profiles as Novel Biomarkers for Polypoidal Choroidal Vasculopathy and Neovascular Age-Related Macular Degeneration
by: Xinyuan Zhang, et al.
Published: (2022-07-01)

Research status of subretinal fluid in rhegmatogenous retinal detachment after scleral buckling surgery
by: Xiao-Nan Shi, et al.
Published: (2018-09-01)

Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients
by: Huiying Zhou, et al.
Published: (2020-01-01)