Physical Exercise Repairs Obstructive Jaundice-Induced Damage to Intestinal Mucosal Barrier Function via H2S-Mediated Regulation of the HMGB1/Toll Like Receptors 4/Nuclear Factor Kappa B Pathway

Physical Exercise Repairs Obstructive Jaundice-Induced Damage to Intestinal Mucosal Barrier Function via H2S-Mediated Regulation of the HMGB1/Toll Like Receptors 4/Nuclear Factor Kappa B Pathway

The present study aimed to determine the effect of aerobic exercise on improving damage to intestinal mucosal barrier function caused by obstructive jaundice (OJ) and explore the mechanism. Fifty male KM mice were divided into five groups: sham operation group (S), model group (M), exercise group (T...

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Bibliographic Details
Main Authors: Changfeng Shao, Ye Li, Jiaqin Chen, Lan Zheng, Wei Chen, Qi Peng, Rui Chen, Afang Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Physiology
Subjects:
aerobic exercise
hydrogen sulfide
obstructive jaundice
intestinal mucosal barrier
HMGB1/TLR4
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.732780/full

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