Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

Inhibition of TRPM7 suppresses cell proliferation of colon adenocarcinoma in vitro and induces hypomagnesemia in vivo without affecting azoxymethane-induced early colon cancer in mice

Abstract Background Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel involved in cellular and systemic Mg2+ homeostasis. Abnormal expression o...

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Bibliographic Details
Main Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner, Andrea Fleig
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Cell Communication and Signaling
Subjects:
Dysplastic aberrant crypt foci
Colon cancer
TRPM7
Mg2+ (magnesium) channel
Waixenicin A
Online Access:http://link.springer.com/article/10.1186/s12964-017-0187-9

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