Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24108-6 |
| _version_ | 1818570635217993728 |
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| author | Haohao Huang Songyang Zhang Yuanyuan Li Zhaodan Liu Lanjuan Mi Yan Cai Xinzheng Wang Lishu Chen Haowen Ran Dake Xiao Fangye Li Jiaqi Wu Tingting Li Qiuying Han Liang Chen Xin Pan Huiyan Li Tao Li Kun He Ailing Li Xuemin Zhang Tao Zhou Qing Xia Jianghong Man |
| author_facet | Haohao Huang Songyang Zhang Yuanyuan Li Zhaodan Liu Lanjuan Mi Yan Cai Xinzheng Wang Lishu Chen Haowen Ran Dake Xiao Fangye Li Jiaqi Wu Tingting Li Qiuying Han Liang Chen Xin Pan Huiyan Li Tao Li Kun He Ailing Li Xuemin Zhang Tao Zhou Qing Xia Jianghong Man |
| author_sort | Haohao Huang |
| collection | DOAJ |
| description | How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells. |
| first_indexed | 2024-12-14T13:44:33Z |
| format | Article |
| id | doaj.art-717939013c2d493084da56349c8594b5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:44:33Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-717939013c2d493084da56349c8594b52022-12-21T22:59:21ZengNature PortfolioNature Communications2041-17232021-06-0112111610.1038/s41467-021-24108-6Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistanceHaohao Huang0Songyang Zhang1Yuanyuan Li2Zhaodan Liu3Lanjuan Mi4Yan Cai5Xinzheng Wang6Lishu Chen7Haowen Ran8Dake Xiao9Fangye Li10Jiaqi Wu11Tingting Li12Qiuying Han13Liang Chen14Xin Pan15Huiyan Li16Tao Li17Kun He18Ailing Li19Xuemin Zhang20Tao Zhou21Qing Xia22Jianghong Man23State Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisDepartment of Neurosurgery, First Medical Center of PLA General HospitalState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisState Key Laboratory of Proteomics, National Center of Biomedical AnalysisHow ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.https://doi.org/10.1038/s41467-021-24108-6 |
| spellingShingle | Haohao Huang Songyang Zhang Yuanyuan Li Zhaodan Liu Lanjuan Mi Yan Cai Xinzheng Wang Lishu Chen Haowen Ran Dake Xiao Fangye Li Jiaqi Wu Tingting Li Qiuying Han Liang Chen Xin Pan Huiyan Li Tao Li Kun He Ailing Li Xuemin Zhang Tao Zhou Qing Xia Jianghong Man Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance Nature Communications |
| title | Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance |
| title_full | Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance |
| title_fullStr | Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance |
| title_full_unstemmed | Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance |
| title_short | Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance |
| title_sort | suppression of mitochondrial ros by prohibitin drives glioblastoma progression and therapeutic resistance |
| url | https://doi.org/10.1038/s41467-021-24108-6 |
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