In-Strand Metallated Nucleic Acids – Novel Bioinorganic Constructs

Synthetic strategies have been developed for the preparation of in-chain metallated oligonucleotides, in which the oligonucleotide sequence is interrupted by a metal-containing motif. In our work, oligopyridine metal-binding domains are used and approaches are outlined using both labile an...

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Bibliographic Details
Main Authors: Edwin C. Constable, Valérie Chaurin, Catherine E. Housecroft, Amina Wirth
Format: Article
Language:deu
Published: Swiss Chemical Society 2005-11-01
Series:CHIMIA
Subjects:
Online Access:https://chimia.ch/chimia/article/view/4080
Description
Summary:Synthetic strategies have been developed for the preparation of in-chain metallated oligonucleotides, in which the oligonucleotide sequence is interrupted by a metal-containing motif. In our work, oligopyridine metal-binding domains are used and approaches are outlined using both labile and non-labile metal centres.
ISSN:0009-4293
2673-2424