Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurement...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22634-x |
| _version_ | 1818736765953900544 |
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| author | Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li |
| author_facet | Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li |
| author_sort | Nicholas A. Arce |
| collection | DOAJ |
| description | Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurements to monitor the activation of VWF via mechanical unfolding of the autoinhibitory module (AIM). |
| first_indexed | 2024-12-18T00:42:21Z |
| format | Article |
| id | doaj.art-717c9b35a0aa4d4d8a77c1b7e9fbb9c1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:42:21Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-717c9b35a0aa4d4d8a77c1b7e9fbb9c12022-12-21T21:26:52ZengNature PortfolioNature Communications2041-17232021-04-0112111410.1038/s41467-021-22634-xActivation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory moduleNicholas A. Arce0Wenpeng Cao1Alexander K. Brown2Emily R. Legan3Moriah S. Wilson4Emma-Ruoqi Xu5Michael C. Berndt6Jonas Emsley7X. Frank Zhang8Renhao Li9Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of MedicineDepartment of Bioengineering, Department of Mechanical Engineering & Mechanics, Lehigh UniversityBiodiscovery Institute, School of Pharmacy, University of NottinghamAflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of MedicineAflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of MedicineBiodiscovery Institute, School of Pharmacy, University of NottinghamFaculty of Health Sciences, Curtin UniversityBiodiscovery Institute, School of Pharmacy, University of NottinghamDepartment of Bioengineering, Department of Mechanical Engineering & Mechanics, Lehigh UniversityAflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Department of Pediatrics, Emory University School of MedicineVon Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurements to monitor the activation of VWF via mechanical unfolding of the autoinhibitory module (AIM).https://doi.org/10.1038/s41467-021-22634-x |
| spellingShingle | Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module Nature Communications |
| title | Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| title_full | Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| title_fullStr | Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| title_full_unstemmed | Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| title_short | Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| title_sort | activation of von willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module |
| url | https://doi.org/10.1038/s41467-021-22634-x |
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