Using protein geometry to optimize cytotoxicity and the cytokine window of a ROR1 specific T cell engager

Using protein geometry to optimize cytotoxicity and the cytokine window of a ROR1 specific T cell engager

T cell engaging bispecific antibodies have shown clinical proof of concept for hematologic malignancies. Still, cytokine release syndrome, neurotoxicity, and on-target-off-tumor toxicity, especially in the solid tumor setting, represent major obstacles. Second generation TCEs have been described tha...

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Bibliographic Details
Main Authors: Xueyuan Zhou, Felix Klaus Geyer, Dominic Happel, Jeffrey Takimoto, Harald Kolmar, Brian Rabinovich
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
T cell engager
cytokine release syndrome
ROR1
decoupling of cytotoxicity
VHH
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1323049/full

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