Prevalence and Risk Factors of GERD among Stable COPD Patients
Introduction: Gastroesophageal reflux disease (GERD) is one of the most common causes of a chronic cough and is a potential risk factor for chronic obstructive pulmonary disease (COPD) exacerbation. This study aimed to determine the prevalence of GERD in COPD patients. Methods: This was a cross-s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Airlangga
2023-01-01
|
| Series: | Jurnal Respirasi |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/JR/article/view/33108 |
| _version_ | 1811169551395586048 |
|---|---|
| author | Muhammad Hafiz Faisal Yunus Maulana Suryamin Mohammad Fahmi Alatas Adityo Wibowo |
| author_facet | Muhammad Hafiz Faisal Yunus Maulana Suryamin Mohammad Fahmi Alatas Adityo Wibowo |
| author_sort | Muhammad Hafiz |
| collection | DOAJ |
| description | Introduction: Gastroesophageal reflux disease (GERD) is one of the most common causes of a chronic cough and is a potential risk factor for chronic obstructive pulmonary disease (COPD) exacerbation. This study aimed to determine the prevalence of GERD in COPD patients.
Methods: This was a cross-sectional study involving 40 stable COPD patients recruited from outpatient asthma and COPD clinics at Persahabatan National Respiratory Referral Hospital, Jakarta, from May to November 2018. COPD was defined as having a ratio of post-bronchodilator FEV1/FVC < 0.7 and no abnormality on a chest X-ray except emphysematous. Diagnosis of GERD was based on oesophageal mucosal lining break surrounding the distal esophageal sphincter through esophagogastroduodenoscopy (EGD). Asthma patients with known esophageal diseases such as cancer, achalasia, and active peptic ulcer and patients who had used proton pump inhibitors in the last 15 days were excluded.
Results: Patients were divided into GERD (+) (16/40, 40%) and GERD (-) (24/40, 60%). Subjects were predominantly elderly (25/40, 62.5%) and had a smoking history (36/40, 90%). Exacerbation and COPD assessment test (CAT) score was significantly associated with GERD (p < 0.05). No significant difference regarding age, sex, Brinkman Index, lung function, and body mass index (BMI) was found between groups. However, the GERD (+) group showed a slightly higher BMI and more severe airflow obstruction.
Conclusion: The prevalence of GERD in COPD patients found in this study was as high as 40%. A cohort study and preventive strategy of GERD in COPD should be studied further. |
| first_indexed | 2024-04-10T16:44:24Z |
| format | Article |
| id | doaj.art-717d26513fcb459b88d8bc7ceac4e52b |
| institution | Directory Open Access Journal |
| issn | 2407-0831 2621-8372 |
| language | English |
| last_indexed | 2024-04-10T16:44:24Z |
| publishDate | 2023-01-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Jurnal Respirasi |
| spelling | doaj.art-717d26513fcb459b88d8bc7ceac4e52b2023-02-08T03:14:01ZengUniversitas AirlanggaJurnal Respirasi2407-08312621-83722023-01-019116https://doi.org/10.20473/jr.v9-I.1.2023.1-6Prevalence and Risk Factors of GERD among Stable COPD PatientsMuhammad Hafiz0https://orcid.org/0000-0002-2651-2480Faisal Yunus1https://orcid.org/0000-0002-6880-4529Maulana Suryamin2Mohammad Fahmi Alatas3https://orcid.org/0000-0001-5368-6577Adityo Wibowo4https://orcid.org/0000-0002-2867-4969Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia.Division of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Juntendo University, Tokyo, Japan.Introduction: Gastroesophageal reflux disease (GERD) is one of the most common causes of a chronic cough and is a potential risk factor for chronic obstructive pulmonary disease (COPD) exacerbation. This study aimed to determine the prevalence of GERD in COPD patients. Methods: This was a cross-sectional study involving 40 stable COPD patients recruited from outpatient asthma and COPD clinics at Persahabatan National Respiratory Referral Hospital, Jakarta, from May to November 2018. COPD was defined as having a ratio of post-bronchodilator FEV1/FVC < 0.7 and no abnormality on a chest X-ray except emphysematous. Diagnosis of GERD was based on oesophageal mucosal lining break surrounding the distal esophageal sphincter through esophagogastroduodenoscopy (EGD). Asthma patients with known esophageal diseases such as cancer, achalasia, and active peptic ulcer and patients who had used proton pump inhibitors in the last 15 days were excluded. Results: Patients were divided into GERD (+) (16/40, 40%) and GERD (-) (24/40, 60%). Subjects were predominantly elderly (25/40, 62.5%) and had a smoking history (36/40, 90%). Exacerbation and COPD assessment test (CAT) score was significantly associated with GERD (p < 0.05). No significant difference regarding age, sex, Brinkman Index, lung function, and body mass index (BMI) was found between groups. However, the GERD (+) group showed a slightly higher BMI and more severe airflow obstruction. Conclusion: The prevalence of GERD in COPD patients found in this study was as high as 40%. A cohort study and preventive strategy of GERD in COPD should be studied further.https://e-journal.unair.ac.id/JR/article/view/33108chronic respiratory diseasescopdgerdprevalence |
| spellingShingle | Muhammad Hafiz Faisal Yunus Maulana Suryamin Mohammad Fahmi Alatas Adityo Wibowo Prevalence and Risk Factors of GERD among Stable COPD Patients Jurnal Respirasi chronic respiratory diseases copd gerd prevalence |
| title | Prevalence and Risk Factors of GERD among Stable COPD Patients |
| title_full | Prevalence and Risk Factors of GERD among Stable COPD Patients |
| title_fullStr | Prevalence and Risk Factors of GERD among Stable COPD Patients |
| title_full_unstemmed | Prevalence and Risk Factors of GERD among Stable COPD Patients |
| title_short | Prevalence and Risk Factors of GERD among Stable COPD Patients |
| title_sort | prevalence and risk factors of gerd among stable copd patients |
| topic | chronic respiratory diseases copd gerd prevalence |
| url | https://e-journal.unair.ac.id/JR/article/view/33108 |
| work_keys_str_mv | AT muhammadhafiz prevalenceandriskfactorsofgerdamongstablecopdpatients AT faisalyunus prevalenceandriskfactorsofgerdamongstablecopdpatients AT maulanasuryamin prevalenceandriskfactorsofgerdamongstablecopdpatients AT mohammadfahmialatas prevalenceandriskfactorsofgerdamongstablecopdpatients AT adityowibowo prevalenceandriskfactorsofgerdamongstablecopdpatients |