NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammato...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-01-01
|
| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X18301553 |
| _version_ | 1818153529870647296 |
|---|---|
| author | Audrey Ferrand Ziad Al Nabhani Núria Solà Tapias Emmanuel Mas Jean-Pierre Hugot Frédérick Barreau |
| author_facet | Audrey Ferrand Ziad Al Nabhani Núria Solà Tapias Emmanuel Mas Jean-Pierre Hugot Frédérick Barreau |
| author_sort | Audrey Ferrand |
| collection | DOAJ |
| description | Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development. Keywords: Nod2, Cancer, Colitis, Gut, Epithelial cells |
| first_indexed | 2024-12-11T14:12:04Z |
| format | Article |
| id | doaj.art-718013bb58ff4c27b09ae60a1a0b4a0a |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-12-11T14:12:04Z |
| publishDate | 2019-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-718013bb58ff4c27b09ae60a1a0b4a0a2022-12-22T01:03:22ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2019-01-0172357369NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummaryAudrey Ferrand0Ziad Al Nabhani1Núria Solà Tapias2Emmanuel Mas3Jean-Pierre Hugot4Frédérick Barreau5Institut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, FranceLaboratoire Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France; INSERM, UMR 1149, Paris, FranceInstitut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, FranceInstitut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France; Unité de Gastroentérologie, Hépatologie, Maladies Héréditaires du Métabolisme et Nutrition, Hôpital des Enfants, Toulouse, FranceLaboratoire Inflamex, Université Paris-Diderot Sorbonne Paris-Cité, Paris, France; INSERM, UMR 1149, Paris, France; Assistance Publique Hôpitaux de Paris, Hôpital Robert Debré, Paris, FranceInstitut de Recherche en Santé Digestive, Université de Toulouse, Institut National de la Santé et de la Recherche Médicale, Institut National de la Recherche Agronomique, Ecole Nationale Vétérinaire de Toulouse, Université Paul Sabatier, Toulouse, France; Correspondence Address correspondence to: Frédérick Barreau, PhD, INSERM, UMR 1220, Institut de Recherche en Santé Digestive, Toulouse, France. fax: (33) 5-62-74-45-58.Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular pattern recognition receptor that senses bacterial peptidoglycan-conserved motifs in cytosol and stimulates host immune response including epithelial and immune cells. The association of NOD2 mutations with a number of inflammatory pathologies including Crohn’s disease (CD), graft-versus-host diseases, or Blau syndrome, highlights its pivotal role in inflammatory response and the associated-carcinogenesis development. Since its identification in 2001 and its association with CD, the role of NOD2 in epithelial cells and immune cells has been investigated extensively but the precise mechanism by which NOD2 mutations lead to CD and the associated carcinogenesis development is largely unknown. In this review, we present and discuss recent developments about the role of NOD2 inside epithelial cells on the control of the inflammatory process and its linked carcinogenesis development. Keywords: Nod2, Cancer, Colitis, Gut, Epithelial cellshttp://www.sciencedirect.com/science/article/pii/S2352345X18301553 |
| spellingShingle | Audrey Ferrand Ziad Al Nabhani Núria Solà Tapias Emmanuel Mas Jean-Pierre Hugot Frédérick Barreau NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary |
| title_full | NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary |
| title_fullStr | NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary |
| title_full_unstemmed | NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary |
| title_short | NOD2 Expression in Intestinal Epithelial Cells Protects Toward the Development of Inflammation and Associated CarcinogenesisSummary |
| title_sort | nod2 expression in intestinal epithelial cells protects toward the development of inflammation and associated carcinogenesissummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X18301553 |
| work_keys_str_mv | AT audreyferrand nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary AT ziadalnabhani nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary AT nuriasolatapias nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary AT emmanuelmas nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary AT jeanpierrehugot nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary AT frederickbarreau nod2expressioninintestinalepithelialcellsprotectstowardthedevelopmentofinflammationandassociatedcarcinogenesissummary |