<i>N</i>-Glycan on the Non-Consensus N-X-C Glycosylation Site Impacts Activity, Stability, and Localization of the Sd<sup>a</sup> Synthase B4GALNT2

<i>N</i>-Glycan on the Non-Consensus N-X-C Glycosylation Site Impacts Activity, Stability, and Localization of the Sd<sup>a</sup> Synthase B4GALNT2

The Sd<sup>a</sup> carbohydrate epitope and its biosynthetic B4GALNT2 enzyme are expressed in the healthy colon and down-regulated to variable extents in colon cancer. The human <i>B4GALNT2</i> gene drives the expression of a long and a short protein isoform (LF-B4GALNT2 and...

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Bibliographic Details
Main Authors: Virginie Cogez, Dorothée Vicogne, Céline Schulz, Lucie Portier, Giulia Venturi, Jérôme de Ruyck, Mathieu Decloquement, Marc F. Lensink, Guillaume Brysbaert, Fabio Dall’Olio, Sophie Groux-Degroote, Anne Harduin-Lepers
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
B4GALNT2
dimer
glycosyltransferase
<i>N</i>-glycan
unusual N-X-C glycosylation site
Online Access:https://www.mdpi.com/1422-0067/24/4/4139

Internet

https://www.mdpi.com/1422-0067/24/4/4139

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