The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis
Wen-bin Liu,1,* Wen-tao Zhao,2,* Peng Shen,3 Fu-jiang Zhang1 1Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Yunnan Traditional Chinese Medical University, Yunnan 650021, People&rs...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-07-01
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| Series: | Drug Design, Development and Therapy |
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| Online Access: | https://www.dovepress.com/the-effects-of-bisphosphonates-on-osteoporotic-patients-after-lumbar-f-peer-reviewed-article-DDDT |
| _version_ | 1818298595861856256 |
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| author | Liu WB Zhao WT Shen P Zhang FJ |
| author_facet | Liu WB Zhao WT Shen P Zhang FJ |
| author_sort | Liu WB |
| collection | DOAJ |
| description | Wen-bin Liu,1,* Wen-tao Zhao,2,* Peng Shen,3 Fu-jiang Zhang1 1Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Yunnan Traditional Chinese Medical University, Yunnan 650021, People’s Republic of China; 3Department of Rheumatology and Immunology, Tianjin First Center Hospital, Tianjin 300192, People’s Republic of China *These authors contributed equally to this work Purpose: We conducted a meta-analysis of controlled clinical trials to evaluate the efficacy of bisphosphonates in lumbar fusion. Introduction: Bisphosphonates reduce bone resorption and remodeling by osteoclast activity inhibition, inactivation, and apoptosis. However, it remains controversial whether bisphosphonate therapy affects spinal fusion.Methods: We searched MEDLINE, Cochrane CENTRAL, ScienceDirect, EMBASE, and Google Scholar to identify studies reporting the effects of bisphosphonates on osteoporotic patients after lumbar fusion. Secondary sources were identified from the references of the included literature. Pooled data were analyzed using RevMan 5.1.Results: Seven studies met the inclusion criteria. There were significant differences in solid intervertebral fusion (RD=0.07, 95% CI: −0.00 to 0.15, P=0.05), subsequent VCFs (RD=−0.21, 95% CI: −0.30 to −0.12, P<0.00001), pedicle screw loosening (RD=−0.17, 95% CI: −0.28 to −0.05, P=0.006), and cage subsidence (RD=−0.25, 95% CI: −0.42 to −0.07, P=0.005) between two groups. No significant differences between two groups were found regarding implant fixation failure (RD=−0.06, 95% CI: −0.22 to 0.10, P=0.48).Conclusion: This meta-analysis showed that bisphosphonates may increase solid intervertebral fusion and decrease subsequent VCFs, pedicle screw loosening, and cage subsidence. Keywords: bisphosphonates, lumbar, fusion, meta-analysis |
| first_indexed | 2024-12-13T04:37:50Z |
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| id | doaj.art-71821b1e2be94434996f76622d43a5b6 |
| institution | Directory Open Access Journal |
| issn | 1177-8881 |
| language | English |
| last_indexed | 2024-12-13T04:37:50Z |
| publishDate | 2018-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Drug Design, Development and Therapy |
| spelling | doaj.art-71821b1e2be94434996f76622d43a5b62022-12-21T23:59:24ZengDove Medical PressDrug Design, Development and Therapy1177-88812018-07-01Volume 122233224039358The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysisLiu WBZhao WTShen PZhang FJWen-bin Liu,1,* Wen-tao Zhao,2,* Peng Shen,3 Fu-jiang Zhang1 1Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Yunnan Traditional Chinese Medical University, Yunnan 650021, People’s Republic of China; 3Department of Rheumatology and Immunology, Tianjin First Center Hospital, Tianjin 300192, People’s Republic of China *These authors contributed equally to this work Purpose: We conducted a meta-analysis of controlled clinical trials to evaluate the efficacy of bisphosphonates in lumbar fusion. Introduction: Bisphosphonates reduce bone resorption and remodeling by osteoclast activity inhibition, inactivation, and apoptosis. However, it remains controversial whether bisphosphonate therapy affects spinal fusion.Methods: We searched MEDLINE, Cochrane CENTRAL, ScienceDirect, EMBASE, and Google Scholar to identify studies reporting the effects of bisphosphonates on osteoporotic patients after lumbar fusion. Secondary sources were identified from the references of the included literature. Pooled data were analyzed using RevMan 5.1.Results: Seven studies met the inclusion criteria. There were significant differences in solid intervertebral fusion (RD=0.07, 95% CI: −0.00 to 0.15, P=0.05), subsequent VCFs (RD=−0.21, 95% CI: −0.30 to −0.12, P<0.00001), pedicle screw loosening (RD=−0.17, 95% CI: −0.28 to −0.05, P=0.006), and cage subsidence (RD=−0.25, 95% CI: −0.42 to −0.07, P=0.005) between two groups. No significant differences between two groups were found regarding implant fixation failure (RD=−0.06, 95% CI: −0.22 to 0.10, P=0.48).Conclusion: This meta-analysis showed that bisphosphonates may increase solid intervertebral fusion and decrease subsequent VCFs, pedicle screw loosening, and cage subsidence. Keywords: bisphosphonates, lumbar, fusion, meta-analysishttps://www.dovepress.com/the-effects-of-bisphosphonates-on-osteoporotic-patients-after-lumbar-f-peer-reviewed-article-DDDTBisphosphonatesLumbarFusionMeta-analysis |
| spellingShingle | Liu WB Zhao WT Shen P Zhang FJ The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis Drug Design, Development and Therapy Bisphosphonates Lumbar Fusion Meta-analysis |
| title | The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis |
| title_full | The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis |
| title_fullStr | The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis |
| title_full_unstemmed | The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis |
| title_short | The effects of bisphosphonates on osteoporotic patients after lumbar fusion: a meta-analysis |
| title_sort | effects of bisphosphonates on osteoporotic patients after lumbar fusion a meta analysis |
| topic | Bisphosphonates Lumbar Fusion Meta-analysis |
| url | https://www.dovepress.com/the-effects-of-bisphosphonates-on-osteoporotic-patients-after-lumbar-f-peer-reviewed-article-DDDT |
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