An overview of pim kinase as a target in multiple myeloma
Abstract Multiple myeloma (MM) is the second common hematologic malignancy manifesting as a clonal proliferation of plasma cells in the bone marrow. In recent years, high expression and activity of pim kinase have been found to be associated with both the progression and prognosis of a significant p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.5797 |
| _version_ | 1797810429712400384 |
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| author | Zhaoyun Liu Yunhe Zhang Yixuan Guo Hao Wang Rong Fu |
| author_facet | Zhaoyun Liu Yunhe Zhang Yixuan Guo Hao Wang Rong Fu |
| author_sort | Zhaoyun Liu |
| collection | DOAJ |
| description | Abstract Multiple myeloma (MM) is the second common hematologic malignancy manifesting as a clonal proliferation of plasma cells in the bone marrow. In recent years, high expression and activity of pim kinase have been found to be associated with both the progression and prognosis of a significant proportion of malignant diseases. Therefore, pim kinase has become a potential therapeutic target in the treatment of MM and some pim kinase inhibitors have demonstrated good efficacy in clinical trials. Based on nearly the entire literature searched from PubMed in the field of pim kinase in MM, the paper concluded how pim kinase got involved in the proliferation of myeloma cells, the progression of bone disease infiltration, and even in the regulation of the immune microenvironment. Next as a very promising drug, the effectiveness of pim kinase inhibitors as single agents or in combination with other drugs in the treatment of MM was also summarized. Our analysis will guide the clinical use of pim kinase inhibitors for managing tumor load and bone disease in MM patients. |
| first_indexed | 2024-03-13T07:07:38Z |
| format | Article |
| id | doaj.art-718296f81ad54e1a983632cc0d1dd1ca |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-13T07:07:38Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-718296f81ad54e1a983632cc0d1dd1ca2023-06-06T07:30:47ZengWileyCancer Medicine2045-76342023-05-011210117461175910.1002/cam4.5797An overview of pim kinase as a target in multiple myelomaZhaoyun Liu0Yunhe Zhang1Yixuan Guo2Hao Wang3Rong Fu4Department of Hematology Tianjin Medical University General Hospital Tianjin People's Republic of ChinaDepartment of Hematology Tianjin Medical University General Hospital Tianjin People's Republic of ChinaDepartment of Hematology Tianjin Medical University General Hospital Tianjin People's Republic of ChinaDepartment of Hematology Tianjin Medical University General Hospital Tianjin People's Republic of ChinaDepartment of Hematology Tianjin Medical University General Hospital Tianjin People's Republic of ChinaAbstract Multiple myeloma (MM) is the second common hematologic malignancy manifesting as a clonal proliferation of plasma cells in the bone marrow. In recent years, high expression and activity of pim kinase have been found to be associated with both the progression and prognosis of a significant proportion of malignant diseases. Therefore, pim kinase has become a potential therapeutic target in the treatment of MM and some pim kinase inhibitors have demonstrated good efficacy in clinical trials. Based on nearly the entire literature searched from PubMed in the field of pim kinase in MM, the paper concluded how pim kinase got involved in the proliferation of myeloma cells, the progression of bone disease infiltration, and even in the regulation of the immune microenvironment. Next as a very promising drug, the effectiveness of pim kinase inhibitors as single agents or in combination with other drugs in the treatment of MM was also summarized. Our analysis will guide the clinical use of pim kinase inhibitors for managing tumor load and bone disease in MM patients.https://doi.org/10.1002/cam4.5797bone diseaseimmunemultiple myelomapim kinasetumor load |
| spellingShingle | Zhaoyun Liu Yunhe Zhang Yixuan Guo Hao Wang Rong Fu An overview of pim kinase as a target in multiple myeloma Cancer Medicine bone disease immune multiple myeloma pim kinase tumor load |
| title | An overview of pim kinase as a target in multiple myeloma |
| title_full | An overview of pim kinase as a target in multiple myeloma |
| title_fullStr | An overview of pim kinase as a target in multiple myeloma |
| title_full_unstemmed | An overview of pim kinase as a target in multiple myeloma |
| title_short | An overview of pim kinase as a target in multiple myeloma |
| title_sort | overview of pim kinase as a target in multiple myeloma |
| topic | bone disease immune multiple myeloma pim kinase tumor load |
| url | https://doi.org/10.1002/cam4.5797 |
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