Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis

Claudin Barriers on the Brink: How Conflicting Tissue and Cellular Priorities Drive IBD Pathogenesis

Inflammatory bowel diseases (IBDs) are characterized by acute or chronic recurring inflammation of the intestinal mucosa, often with increasing severity over time. Life-long morbidities and diminishing quality of life for IBD patients compel a search for a better understanding of the molecular contr...

Full description

Bibliographic Details
Main Author:	Christopher T. Capaldo
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	International Journal of Molecular Sciences
Subjects:	claudin tight junctions barrier function gut colitis inflammatory bowel disease
Online Access:	https://www.mdpi.com/1422-0067/24/10/8562

Similar Items

Intestinal Barrier, Claudins and Mycotoxins
by: Marta Justyna Kozieł, et al.
Published: (2021-10-01)

Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells
by: Mikio Furuse, et al.
Published: (2022-12-01)

Claudin-4: A New Molecular Target for Epithelial Cancer Therapy
by: Rina Fujiwara-Tani, et al.
Published: (2023-03-01)

Prednisolone Targets Claudins in Mouse Brain Blood Vessels
by: Alexander G. Markov, et al.
Published: (2023-12-01)

Intestinal Claudin-7 deficiency impacts the intestinal microbiota in mice with colitis
by: Yuhan Ding, et al.
Published: (2022-01-01)

Claudins: New Players in Human Fertility and Reproductive System Cancers
by: Marta Justyna Kozieł, et al.
Published: (2020-03-01)

Epithelial Barrier Dysfunction in Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) via Downregulation of Claudin-1
by: Karem Awad, et al.
Published: (2023-12-01)

Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration
by: Mónica Díaz-Coránguez, et al.
Published: (2023-10-01)

Barriers and channels formed by tight junction proteins II /
by: Fromm, Michael, et al.
Published: (2012)

Association of Plasma Claudin-5 with Age and Alzheimer Disease
by: Keisuke Tachibana, et al.
Published: (2024-01-01)

miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis
by: Viviana Scalavino, et al.
Published: (2022-04-01)

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury
by: Alejandro E. Garcia-Flores, et al.
Published: (2022-12-01)

Computational Models of Claudin Assembly in Tight Junctions and Strand Properties
by: Sarah McGuinness, et al.
Published: (2024-03-01)

Matrix metalloproteinase 7 contributes to intestinal barrier dysfunction by degrading tight junction protein Claudin-7
by: Ying Xiao, et al.
Published: (2022-10-01)

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells
by: Helena Hader, et al.
Published: (2023-11-01)

Chimeric Claudins: A New Tool to Study Tight Junction Structure and Function
by: Abigail Taylor, et al.
Published: (2021-05-01)

Prognostic Significance of Aberrant Claudin-6 Expression in Endometrial Cancer
by: Manabu Kojima, et al.
Published: (2020-09-01)

Claudin-11 in health and disease: implications for myelin disorders, hearing, and fertility
by: Sophia C. Gjervan, et al.
Published: (2024-01-01)

Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation
by: Rawad Lashhab, et al.
Published: (2023-11-01)

Special Issue on “The Tight Junction and Its Proteins: More than Just a Barrier”
by: Susanne M. Krug, et al.
Published: (2020-06-01)

Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?
by: Christian Gorzelanny, et al.
Published: (2020-07-01)

CDT of <i>Clostridioides difficile</i> Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers
by: Lucas Heils, et al.
Published: (2023-01-01)

Quercetin Improves Barrier Properties in Porcine Small Intestine but Not in Peyer’s Patches
by: Valeria Cornelius, et al.
Published: (2024-01-01)

Quercetin improves and protects Calu-3 airway epithelial barrier function
by: K. M. DiGuilio, et al.
Published: (2023-11-01)

Chronic Ouabain Targets Pore-Forming Claudin-2 and Ameliorates Radiation-Induced Damage to the Rat Intestinal Tissue Barrier
by: Alexander G. Markov, et al.
Published: (2023-12-01)

Claudin-4-adhesion signaling drives breast cancer metabolism and progression via liver X receptor β
by: Yuko Murakami-Nishimagi, et al.
Published: (2023-04-01)

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids
by: Ayk Waldow, et al.
Published: (2023-07-01)

Reduced Claudin-12 Expression Predicts Poor Prognosis in Cervical Cancer
by: Abidur Rahman, et al.
Published: (2021-04-01)

The CLDN5 gene at the blood-brain barrier in health and disease
by: Yosuke Hashimoto, et al.
Published: (2023-03-01)

Tight Junction Protein Claudin-12 Is Involved in Cell Migration during Metastasis
by: Desislava Kolchakova, et al.
Published: (2021-04-01)

The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis
by: Adrian Georg Simon, et al.
Published: (2023-08-01)

Correlation analysis of circulating tumor cells and Claudin-4 in breast cancer
by: Jie Chai, et al.
Published: (2023-07-01)

High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats
by: Junzhi Yang, et al.
Published: (2022-04-01)

Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1
by: Linda Droessler, et al.
Published: (2021-08-01)

Claudin-10b cation channels in tight junction strands: Octameric-interlocked pore barrels constitute paracellular channels with low water permeability
by: Santhosh Kumar Nagarajan, et al.
Published: (2023-01-01)

Concerted action of berberine in the porcine intestinal epithelial model IPEC‐J2: Effects on tight junctions and apoptosis
by: Valeria Cornelius, et al.
Published: (2022-04-01)

Cannabidiol attenuates inflammatory impairment of intestinal cells expanding biomaterial-based therapeutic approaches
by: Elisa Boehm, et al.
Published: (2023-12-01)

Claudin-10 Expression and the Gene Expression Pattern of Thick Ascending Limb Cells
by: Gaelle Brideau, et al.
Published: (2024-04-01)

Molecular Dynamics Simulations of Claudin-10a and -10b Ion Channels: With Similar Architecture, Different Pore Linings Determine the Opposite Charge Selectivity
by: Santhosh Kumar Nagarajan, et al.
Published: (2024-03-01)

Hazara orthonairovirus nucleoprotein facilitates viral cell-to-cell spread by modulating tight junction protein, claudin-1
by: Keisuke Ohta, et al.
Published: (2023-05-01)