Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder
Abstract Objective The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐aquaporin‐4 (AQP4) antibody‐positive neuromyelitis optica spectrum disorder (NMOSD). Methods Herein, we present...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2083 |
| _version_ | 1819088183832346624 |
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| author | Tetsuya Akaishi Noriko Himori Takayuki Takeshita Kazuo Fujihara Tatsuro Misu Toshiyuki Takahashi Juichi Fujimori Tadashi Ishii Masashi Aoki Toru Nakazawa Ichiro Nakashima |
| author_facet | Tetsuya Akaishi Noriko Himori Takayuki Takeshita Kazuo Fujihara Tatsuro Misu Toshiyuki Takahashi Juichi Fujimori Tadashi Ishii Masashi Aoki Toru Nakazawa Ichiro Nakashima |
| author_sort | Tetsuya Akaishi |
| collection | DOAJ |
| description | Abstract Objective The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐aquaporin‐4 (AQP4) antibody‐positive neuromyelitis optica spectrum disorder (NMOSD). Methods Herein, we present three patients who developed acute optic neuritis with visual disturbances after accidental minor trauma to their eyes, without any fundus abnormality or orbital floor fractures present. Results Two of the three patients had a preceding history of neurological disturbances compatible with NMOSD (e.g., myelitis, area postrema syndrome) before the occurrence of trauma. One patient was rapidly treated with steroid pulse therapy and plasmapheresis, and he fully recovered visual acuity. The other two, who were left untreated in the acute phase, had sequelae of severe visual disturbances in the affected eyes. Conclusions These cases suggest possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐AQP4 antibodies. Avoiding ocular trauma and early administration of steroid pulse therapy in response to optic neuritis after trauma are desired in such cases. |
| first_indexed | 2024-12-21T21:48:00Z |
| format | Article |
| id | doaj.art-718305b90124484aaa90f48f31396a23 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-21T21:48:00Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-718305b90124484aaa90f48f31396a232022-12-21T18:49:09ZengWileyBrain and Behavior2162-32792021-05-01115n/an/a10.1002/brb3.2083Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorderTetsuya Akaishi0Noriko Himori1Takayuki Takeshita2Kazuo Fujihara3Tatsuro Misu4Toshiyuki Takahashi5Juichi Fujimori6Tadashi Ishii7Masashi Aoki8Toru Nakazawa9Ichiro Nakashima10Department of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Ophthalmology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Ophthalmology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Multiple Sclerosis Therapeutics Fukushima Medical University Fukushima JapanDepartment of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Neurology Tohoku Medical and Pharmaceutical University Sendai JapanDepartment of Education and Support for Regional Medicine Tohoku University Hospital Sendai JapanDepartment of Neurology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Ophthalmology Tohoku University Graduate School of Medicine Sendai JapanDepartment of Neurology Tohoku Medical and Pharmaceutical University Sendai JapanAbstract Objective The aim of this study was to report the possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐aquaporin‐4 (AQP4) antibody‐positive neuromyelitis optica spectrum disorder (NMOSD). Methods Herein, we present three patients who developed acute optic neuritis with visual disturbances after accidental minor trauma to their eyes, without any fundus abnormality or orbital floor fractures present. Results Two of the three patients had a preceding history of neurological disturbances compatible with NMOSD (e.g., myelitis, area postrema syndrome) before the occurrence of trauma. One patient was rapidly treated with steroid pulse therapy and plasmapheresis, and he fully recovered visual acuity. The other two, who were left untreated in the acute phase, had sequelae of severe visual disturbances in the affected eyes. Conclusions These cases suggest possible association between minor trauma to the eyes and the subsequent occurrence of optic neuritis in patients with serum anti‐AQP4 antibodies. Avoiding ocular trauma and early administration of steroid pulse therapy in response to optic neuritis after trauma are desired in such cases.https://doi.org/10.1002/brb3.2083anti‐aquaporin‐4 antibodiesneuromyelitis optica spectrum disordersocular traumaoptic neuritis |
| spellingShingle | Tetsuya Akaishi Noriko Himori Takayuki Takeshita Kazuo Fujihara Tatsuro Misu Toshiyuki Takahashi Juichi Fujimori Tadashi Ishii Masashi Aoki Toru Nakazawa Ichiro Nakashima Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder Brain and Behavior anti‐aquaporin‐4 antibodies neuromyelitis optica spectrum disorders ocular trauma optic neuritis |
| title | Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder |
| title_full | Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder |
| title_fullStr | Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder |
| title_full_unstemmed | Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder |
| title_short | Optic neuritis after ocular trauma in anti‐aquaporin‐4 antibody‐positive neuromyelitis optica spectrum disorder |
| title_sort | optic neuritis after ocular trauma in anti aquaporin 4 antibody positive neuromyelitis optica spectrum disorder |
| topic | anti‐aquaporin‐4 antibodies neuromyelitis optica spectrum disorders ocular trauma optic neuritis |
| url | https://doi.org/10.1002/brb3.2083 |
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