New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation

New thioxothiazolidinyl-acetamides derivatives as potent urease inhibitors: design, synthesis, in vitro inhibition, and molecular dynamic simulation

Abstract To identify potent urease inhibitors, in the current study, a series of thioxothiazolidinyl-acetamides were designed and synthesized. The prepared compounds were characterized by spectroscopic techniques, including FTIR, 1HNMR, 13CNMR, and elemental analysis. In the enzymatic assessments, i...

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Bibliographic Details
Main Authors: Navid Dastyafteh, Milad Noori, Mohammad Nazari Montazer, Kamiar Zomorodian, Somayeh Yazdanpanah, Aida Iraji, Minoo Khalili Ghomi, Shahrzad Javanshir, Mehdi Asadi, Mehdi Dianatpour, Mahmood Biglar, Bagher Larijani, Massoud Amanlou, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-27234-3

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