The yin/yang balance of the MHC-self-immunopeptidome
The MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells. In regulatory T cells, the TCR signaling associated with MHC-peptide recognition induces antigen specific as well as by...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035363/full |
| _version_ | 1811255535879585792 |
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| author | Laura Santambrogio Alessandra Franco |
| author_facet | Laura Santambrogio Alessandra Franco |
| author_sort | Laura Santambrogio |
| collection | DOAJ |
| description | The MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells. In regulatory T cells, the TCR signaling associated with MHC-peptide recognition induces antigen specific as well as bystander immunosuppression. On the other hand, TCR activation of conventional T cells is associated with protective immunity. As such the peripheral T cell repertoire is populated by a number of T cells with different phenotypes and different TCRs, which can recognize the same MHC-self-peptide complex, resulting in opposite immunological outcomes. This article summarizes what is known about regulatory and conventional T cell recognition of the MHC-self-immunopeptidome at steady state and in inflammatory conditions associated with increased T and B cell self-reactivity, discussing how changes in the MHC-ligandome including epitope copy number and post-translational modifications can tilt the balance toward the expansion of pro-inflammatory or regulatory T cells. |
| first_indexed | 2024-04-12T17:25:25Z |
| format | Article |
| id | doaj.art-7183d952451943518ccf31168fd0879f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T17:25:25Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-7183d952451943518ccf31168fd0879f2022-12-22T03:23:19ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10353631035363The yin/yang balance of the MHC-self-immunopeptidomeLaura Santambrogio0Alessandra Franco1Department of Radiation Oncology, Physiology and Biophysics, Englander Institute of Precision Medicine, Weill Cornell Medicine, New York, NY, United StatesUniversity of California San Diego School of Medicine, Department of Pediatrics, La Jolla, CA, United StatesThe MHC-self immunopeptidome of professional antigen presenting cells is a cognate ligand for the TCRs expressed on both conventional and thymic-derived natural regulatory T cells. In regulatory T cells, the TCR signaling associated with MHC-peptide recognition induces antigen specific as well as bystander immunosuppression. On the other hand, TCR activation of conventional T cells is associated with protective immunity. As such the peripheral T cell repertoire is populated by a number of T cells with different phenotypes and different TCRs, which can recognize the same MHC-self-peptide complex, resulting in opposite immunological outcomes. This article summarizes what is known about regulatory and conventional T cell recognition of the MHC-self-immunopeptidome at steady state and in inflammatory conditions associated with increased T and B cell self-reactivity, discussing how changes in the MHC-ligandome including epitope copy number and post-translational modifications can tilt the balance toward the expansion of pro-inflammatory or regulatory T cells.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035363/fullMHC class IMHC class IIimmune toleranceregulatory T cellsantigen processingantigen presentation |
| spellingShingle | Laura Santambrogio Alessandra Franco The yin/yang balance of the MHC-self-immunopeptidome Frontiers in Immunology MHC class I MHC class II immune tolerance regulatory T cells antigen processing antigen presentation |
| title | The yin/yang balance of the MHC-self-immunopeptidome |
| title_full | The yin/yang balance of the MHC-self-immunopeptidome |
| title_fullStr | The yin/yang balance of the MHC-self-immunopeptidome |
| title_full_unstemmed | The yin/yang balance of the MHC-self-immunopeptidome |
| title_short | The yin/yang balance of the MHC-self-immunopeptidome |
| title_sort | yin yang balance of the mhc self immunopeptidome |
| topic | MHC class I MHC class II immune tolerance regulatory T cells antigen processing antigen presentation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035363/full |
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