Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice

Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Among the family members, the Cib1 and Cib2 genes are expressed in mouse cochlear hair cells, and mutations in th...

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Detalles Bibliográficos
Main Authors: Yanfei Wang, Jie Li, Xuerui Yao, Wei Li, Haibo Du, Mingliang Tang, Wei Xiong, Renjie Chai, Zhigang Xu
Formato: Artigo
Idioma:English
Publicado: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Acceso en liña:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00401/full