FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients
Nonalcoholic fatty liver disease (NAFLD)-associated liver fibrosis is likely related to coronary artery disease (CAD) by the mediation of systemic inflammation. This study aimed at evaluating the predictive value of neutrophil-to-lymphocyte-ratio (NLR) and fibrosis-4 index (FIB-4), indices of inflam...
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MDPI AG
2022-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/1/76 |
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| author | Melania Gaggini Fabrizio Minichilli Francesca Gorini Serena Del Turco Patrizia Landi Alessandro Pingitore Cristina Vassalle |
| author_facet | Melania Gaggini Fabrizio Minichilli Francesca Gorini Serena Del Turco Patrizia Landi Alessandro Pingitore Cristina Vassalle |
| author_sort | Melania Gaggini |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD)-associated liver fibrosis is likely related to coronary artery disease (CAD) by the mediation of systemic inflammation. This study aimed at evaluating the predictive value of neutrophil-to-lymphocyte-ratio (NLR) and fibrosis-4 index (FIB-4), indices of inflammation and fibrosis, respectively, on CAD mortality. Data from 1460 CAD patients (1151 males, age: 68 ± 10 years, mean ± SD) were retrospectively analyzed. Over a median follow-up of 26 months (interquartile range (IQR) 12–45), 94 deaths were recorded. Kaplan–Meier survival analysis revealed worse outcomes in patients with elevation of one or both biomarkers (FIB-4 > 3.25 or/and NLR > 2.04, log-rank <i>p</i>-value < 0.001). In multivariate Cox regression analysis, the elevation of one biomarker (NLR or FIB-4) still confers a significant independent risk for mortality (hazard ratio (HR) = 1.7, 95% confidence interval (95% CI): 1.1–2.7, <i>p</i> = 0.023), whereas an increase in both biomarkers confers a risk corresponding to HR = 3.5 (95% CI: 1.6–7.8, <i>p</i> = 0.002). Categorization of patients with elevated FIB-4/NLR could provide valuable information for risk stratification and reduction of residual risk in CAD patients. |
| first_indexed | 2024-03-09T13:30:11Z |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T13:30:11Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-7184a74cd60142fbb7384ac83612256d2023-11-30T21:19:06ZengMDPI AGBiomedicines2227-90592022-12-011117610.3390/biomedicines11010076FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease PatientsMelania Gaggini0Fabrizio Minichilli1Francesca Gorini2Serena Del Turco3Patrizia Landi4Alessandro Pingitore5Cristina Vassalle6Institute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyInstitute of Clinical Physiology, National Research Council, 56124 Pisa, ItalyFondazione Gabriele Monasterio, CNR-Regione Toscana, 56124 Pisa, ItalyNonalcoholic fatty liver disease (NAFLD)-associated liver fibrosis is likely related to coronary artery disease (CAD) by the mediation of systemic inflammation. This study aimed at evaluating the predictive value of neutrophil-to-lymphocyte-ratio (NLR) and fibrosis-4 index (FIB-4), indices of inflammation and fibrosis, respectively, on CAD mortality. Data from 1460 CAD patients (1151 males, age: 68 ± 10 years, mean ± SD) were retrospectively analyzed. Over a median follow-up of 26 months (interquartile range (IQR) 12–45), 94 deaths were recorded. Kaplan–Meier survival analysis revealed worse outcomes in patients with elevation of one or both biomarkers (FIB-4 > 3.25 or/and NLR > 2.04, log-rank <i>p</i>-value < 0.001). In multivariate Cox regression analysis, the elevation of one biomarker (NLR or FIB-4) still confers a significant independent risk for mortality (hazard ratio (HR) = 1.7, 95% confidence interval (95% CI): 1.1–2.7, <i>p</i> = 0.023), whereas an increase in both biomarkers confers a risk corresponding to HR = 3.5 (95% CI: 1.6–7.8, <i>p</i> = 0.002). Categorization of patients with elevated FIB-4/NLR could provide valuable information for risk stratification and reduction of residual risk in CAD patients.https://www.mdpi.com/2227-9059/11/1/76fibrosis-4 indexFIB-4neutrophil-to-lymphocyte-ratioNLRhepatic fibrosissystemic inflammation |
| spellingShingle | Melania Gaggini Fabrizio Minichilli Francesca Gorini Serena Del Turco Patrizia Landi Alessandro Pingitore Cristina Vassalle FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients Biomedicines fibrosis-4 index FIB-4 neutrophil-to-lymphocyte-ratio NLR hepatic fibrosis systemic inflammation |
| title | FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients |
| title_full | FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients |
| title_fullStr | FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients |
| title_full_unstemmed | FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients |
| title_short | FIB-4 Index and Neutrophil-to-Lymphocyte-Ratio as Death Predictor in Coronary Artery Disease Patients |
| title_sort | fib 4 index and neutrophil to lymphocyte ratio as death predictor in coronary artery disease patients |
| topic | fibrosis-4 index FIB-4 neutrophil-to-lymphocyte-ratio NLR hepatic fibrosis systemic inflammation |
| url | https://www.mdpi.com/2227-9059/11/1/76 |
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