Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis
Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Kno...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00339/full |
| _version_ | 1818841120768000000 |
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| author | Silvia Tenembaum E. Ann Yeh The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC) Hesham Abboud Raed Alroughani Ayse Altintas Lilyana Amezcua Metha Apiwattanakul Nasrin Asgari Brenda Banwell Jeffrey Bennett Denis Bichuetti Terrence F. Blaschke James Bowen Alexey Boyko Alexander Brandt Simon Broadley Wolfgang Brück Edgar Carnero Contentti Robert Carruthers Tanuja Chitnis Jeffrey Cohen Guillermo Delgado-García, Irena Dujmovic Basuroski Nikos Evangelou Kazuo Fujihara Andrew Goodman Benjamin Greenberg May Han Joachim Havla Kerstin Hellwig Jyh Yung Hor Raffaele Iorio Anu Jacob Sven Jarius Jorge Andres Jimenez Arango Ilana Katz Sand Kim Ho Jin Kim Sung Min Dorlan Kimbrough Najib Kissani Eric Klawiter Ingo Kleiter Marco Lana-Peixoto Maria Isabel Leite Michael Levy Yaou Liu Fred Lublin Youssoufa Maiga Yang Mao-Draayer Romain Marignier Sara Mariotto Marcelo Matiello Esther Melamed Callene Momtazee Ichiro Nakashima Jayne Ness Celia Oreja-Guevara Jacqueline Palace Lekha Pandit Friedemann Paul Sarah Planchon Pope Pröbstel Anne-Katrin Peiqing Qian Chao Quan Pavle Repovic Claire Riley Marius Ringelstein Dalia Rotstein Charité Klemens Ruprecht Sá Maria José Albert Saiz Douglas Sato Eslam Shosha Nancy Sicotte Sasitorn Siritho Aksel Siva Terry J. Smith de Castillo Ibis Soto Silva Tenembaum Leticia Tornes Pablo Villoslada Dean Wingerchuk Jens Wüfel Bassem Yamout Michael R. Yeaman E. Ann Yeh Scott Zamvil |
| author_facet | Silvia Tenembaum E. Ann Yeh The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC) Hesham Abboud Raed Alroughani Ayse Altintas Lilyana Amezcua Metha Apiwattanakul Nasrin Asgari Brenda Banwell Jeffrey Bennett Denis Bichuetti Terrence F. Blaschke James Bowen Alexey Boyko Alexander Brandt Simon Broadley Wolfgang Brück Edgar Carnero Contentti Robert Carruthers Tanuja Chitnis Jeffrey Cohen Guillermo Delgado-García, Irena Dujmovic Basuroski Nikos Evangelou Kazuo Fujihara Andrew Goodman Benjamin Greenberg May Han Joachim Havla Kerstin Hellwig Jyh Yung Hor Raffaele Iorio Anu Jacob Sven Jarius Jorge Andres Jimenez Arango Ilana Katz Sand Kim Ho Jin Kim Sung Min Dorlan Kimbrough Najib Kissani Eric Klawiter Ingo Kleiter Marco Lana-Peixoto Maria Isabel Leite Michael Levy Yaou Liu Fred Lublin Youssoufa Maiga Yang Mao-Draayer Romain Marignier Sara Mariotto Marcelo Matiello Esther Melamed Callene Momtazee Ichiro Nakashima Jayne Ness Celia Oreja-Guevara Jacqueline Palace Lekha Pandit Friedemann Paul Sarah Planchon Pope Pröbstel Anne-Katrin Peiqing Qian Chao Quan Pavle Repovic Claire Riley Marius Ringelstein Dalia Rotstein Charité Klemens Ruprecht Sá Maria José Albert Saiz Douglas Sato Eslam Shosha Nancy Sicotte Sasitorn Siritho Aksel Siva Terry J. Smith de Castillo Ibis Soto Silva Tenembaum Leticia Tornes Pablo Villoslada Dean Wingerchuk Jens Wüfel Bassem Yamout Michael R. Yeaman E. Ann Yeh Scott Zamvil |
| author_sort | Silvia Tenembaum |
| collection | DOAJ |
| description | Neuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown in recent years, particularly in light of newer information regarding the importance of not only antibodies to aquaporin 4 (AQP4-IgG) but also myelin oligodendrocyte glycoprotein (MOG-IgG) in children manifesting clinically with this syndrome. In this review, we describe the current state of the knowledge related to clinical manifestations, diagnosis, and chronic therapies for children with NMOSD, with emphasis on literature that has been published in the last 5 years. Following the review, we propose recommendations for the assessment/follow up clinical care, and treatment of this population. |
| first_indexed | 2024-12-19T04:21:02Z |
| format | Article |
| id | doaj.art-7184cbf2b4c54c13a5376db0a1799c9b |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-19T04:21:02Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-7184cbf2b4c54c13a5376db0a1799c9b2022-12-21T20:36:09ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-06-01810.3389/fped.2020.00339556350Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and DiagnosisSilvia Tenembaum0E. Ann Yeh1The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC)Hesham AbboudRaed AlroughaniAyse AltintasLilyana AmezcuaMetha ApiwattanakulNasrin AsgariBrenda BanwellJeffrey BennettDenis BichuettiTerrence F. BlaschkeJames BowenAlexey BoykoAlexander BrandtSimon BroadleyWolfgang BrückEdgar Carnero ContenttiRobert CarruthersTanuja ChitnisJeffrey CohenGuillermo Delgado-García,Irena Dujmovic BasuroskiNikos EvangelouKazuo FujiharaAndrew GoodmanBenjamin GreenbergMay HanJoachim HavlaKerstin HellwigJyh Yung HorRaffaele IorioAnu JacobSven JariusJorge Andres Jimenez ArangoIlana Katz SandKim Ho JinKim Sung MinDorlan KimbroughNajib KissaniEric KlawiterIngo KleiterMarco Lana-PeixotoMaria Isabel LeiteMichael LevyYaou LiuFred LublinYoussoufa MaigaYang Mao-DraayerRomain MarignierSara MariottoMarcelo MatielloEsther MelamedCallene MomtazeeIchiro NakashimaJayne NessCelia Oreja-GuevaraJacqueline PalaceLekha PanditFriedemann PaulSarah Planchon PopePröbstel Anne-KatrinPeiqing QianChao QuanPavle RepovicClaire RileyMarius RingelsteinDalia RotsteinCharité Klemens RuprechtSá Maria JoséAlbert SaizDouglas SatoEslam ShoshaNancy SicotteSasitorn SirithoAksel SivaTerry J. Smithde Castillo Ibis SotoSilva TenembaumLeticia TornesPablo VillosladaDean WingerchukJens WüfelBassem YamoutMichael R. YeamanE. Ann YehScott ZamvilDepartment of Neurology, National Pediatric Hospital Dr. J. Garrahan, Buenos Aires, ArgentinaDivision of Neurology, Department of Pediatrics, SickKids Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, CanadaNeuromyelitis Optica Spectrum Disorder (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) primarily affecting the optic nerves and spinal cord, but also involving other regions of the CNS including the area postrema, periaqueductal gray matter, and hypothalamus. Knowledge related to pediatric manifestations of NMOSD has grown in recent years, particularly in light of newer information regarding the importance of not only antibodies to aquaporin 4 (AQP4-IgG) but also myelin oligodendrocyte glycoprotein (MOG-IgG) in children manifesting clinically with this syndrome. In this review, we describe the current state of the knowledge related to clinical manifestations, diagnosis, and chronic therapies for children with NMOSD, with emphasis on literature that has been published in the last 5 years. Following the review, we propose recommendations for the assessment/follow up clinical care, and treatment of this population.https://www.frontiersin.org/article/10.3389/fped.2020.00339/fullpediatricneuroinflammationNMOSDMOGtreatmentdiagnosis |
| spellingShingle | Silvia Tenembaum E. Ann Yeh The Guthy-Jackson Foundation International Clinical Consortium (GJCF-ICC) Hesham Abboud Raed Alroughani Ayse Altintas Lilyana Amezcua Metha Apiwattanakul Nasrin Asgari Brenda Banwell Jeffrey Bennett Denis Bichuetti Terrence F. Blaschke James Bowen Alexey Boyko Alexander Brandt Simon Broadley Wolfgang Brück Edgar Carnero Contentti Robert Carruthers Tanuja Chitnis Jeffrey Cohen Guillermo Delgado-García, Irena Dujmovic Basuroski Nikos Evangelou Kazuo Fujihara Andrew Goodman Benjamin Greenberg May Han Joachim Havla Kerstin Hellwig Jyh Yung Hor Raffaele Iorio Anu Jacob Sven Jarius Jorge Andres Jimenez Arango Ilana Katz Sand Kim Ho Jin Kim Sung Min Dorlan Kimbrough Najib Kissani Eric Klawiter Ingo Kleiter Marco Lana-Peixoto Maria Isabel Leite Michael Levy Yaou Liu Fred Lublin Youssoufa Maiga Yang Mao-Draayer Romain Marignier Sara Mariotto Marcelo Matiello Esther Melamed Callene Momtazee Ichiro Nakashima Jayne Ness Celia Oreja-Guevara Jacqueline Palace Lekha Pandit Friedemann Paul Sarah Planchon Pope Pröbstel Anne-Katrin Peiqing Qian Chao Quan Pavle Repovic Claire Riley Marius Ringelstein Dalia Rotstein Charité Klemens Ruprecht Sá Maria José Albert Saiz Douglas Sato Eslam Shosha Nancy Sicotte Sasitorn Siritho Aksel Siva Terry J. Smith de Castillo Ibis Soto Silva Tenembaum Leticia Tornes Pablo Villoslada Dean Wingerchuk Jens Wüfel Bassem Yamout Michael R. Yeaman E. Ann Yeh Scott Zamvil Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis Frontiers in Pediatrics pediatric neuroinflammation NMOSD MOG treatment diagnosis |
| title | Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis |
| title_full | Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis |
| title_fullStr | Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis |
| title_full_unstemmed | Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis |
| title_short | Pediatric NMOSD: A Review and Position Statement on Approach to Work-Up and Diagnosis |
| title_sort | pediatric nmosd a review and position statement on approach to work up and diagnosis |
| topic | pediatric neuroinflammation NMOSD MOG treatment diagnosis |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00339/full |
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