Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease
Introduction: Gastrointestinal Short Form Questionnaire (GSFQ) is a questionnaire for gastroesophageal reflux disease (GERD) diagnosis, with a version in Spanish language, not yet compared to an objective test. Aims: To establish GSFQ diagnostic performance against 24-hour pH monitoring carried out...
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Aran Ediciones
2016-04-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400002&lng=en&tlng=en |
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| author | Carlos Teruel-Sánchez-Vegazo Vicenta Faro-Leal Alfonso Muriel-García Norberto Mañas-Gallardo |
| author_facet | Carlos Teruel-Sánchez-Vegazo Vicenta Faro-Leal Alfonso Muriel-García Norberto Mañas-Gallardo |
| author_sort | Carlos Teruel-Sánchez-Vegazo |
| collection | DOAJ |
| description | Introduction: Gastrointestinal Short Form Questionnaire (GSFQ) is a questionnaire for gastroesophageal reflux disease (GERD) diagnosis, with a version in Spanish language, not yet compared to an objective test. Aims: To establish GSFQ diagnostic performance against 24-hour pH monitoring carried out in two tertiary care hospitals. Methods: Consecutive adult patients with typical GERD symptoms (heartburn, regurgitation) referred for pH monitoring fulfilled the GSFQ (score range 0-30, proportional to probability of GERD). Diagnosis of GERD was established when acid exposure time in distal esophagus was superior to 4.5% or symptom association probability was greater than 95%. Receiver-operator characteristic (ROC) curves were calculated and best cut-off score determined, with corresponding sensitivity, specificity and likelihood ratios (LR) (95% confidence interval for each). Results: One hundred and fifty-two patients were included (59.9% women, age 47.9 ± 13.9; 97.4% heartburn; 71.3% regurgitation). pH monitoring was abnormal in 65.8%. Mean GSFQ score was 11.2 ± 6. Area under ROC was 56.5% (47.0-65.9%). Optimal cut-off score was 13 or greater: sensitivity 40% (30.3-50.3%), specificity 71.2% (56.9-82.9%), positive LR 1.39 (0.85-2.26) and negative LR 0.84 (0.67-1.07). Exclusion of questions 1 and 3 of the original GSFQ, easily interpreted as referred to dyspepsia and not GERD, improved only marginally the diagnostic performance: AUROC 59.1%. Conclusion: The GSFQ does not predict results of pH monitoring in patients with typical symptoms in a tertiary care setting. |
| first_indexed | 2024-04-11T23:36:46Z |
| format | Article |
| id | doaj.art-71860805e4474d898c5660d97ee43600 |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-04-11T23:36:46Z |
| publishDate | 2016-04-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-71860805e4474d898c5660d97ee436002022-12-22T03:56:55ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082016-04-011084174180S1130-01082016000400002Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux diseaseCarlos Teruel-Sánchez-Vegazo0Vicenta Faro-Leal1Alfonso Muriel-García2Norberto Mañas-Gallardo3Hospital Universitario Ramón y CajalHospital Universitario Ramón y CajalHospital Universitario Ramón y CajalHospital Madrid Norte SanchinarroIntroduction: Gastrointestinal Short Form Questionnaire (GSFQ) is a questionnaire for gastroesophageal reflux disease (GERD) diagnosis, with a version in Spanish language, not yet compared to an objective test. Aims: To establish GSFQ diagnostic performance against 24-hour pH monitoring carried out in two tertiary care hospitals. Methods: Consecutive adult patients with typical GERD symptoms (heartburn, regurgitation) referred for pH monitoring fulfilled the GSFQ (score range 0-30, proportional to probability of GERD). Diagnosis of GERD was established when acid exposure time in distal esophagus was superior to 4.5% or symptom association probability was greater than 95%. Receiver-operator characteristic (ROC) curves were calculated and best cut-off score determined, with corresponding sensitivity, specificity and likelihood ratios (LR) (95% confidence interval for each). Results: One hundred and fifty-two patients were included (59.9% women, age 47.9 ± 13.9; 97.4% heartburn; 71.3% regurgitation). pH monitoring was abnormal in 65.8%. Mean GSFQ score was 11.2 ± 6. Area under ROC was 56.5% (47.0-65.9%). Optimal cut-off score was 13 or greater: sensitivity 40% (30.3-50.3%), specificity 71.2% (56.9-82.9%), positive LR 1.39 (0.85-2.26) and negative LR 0.84 (0.67-1.07). Exclusion of questions 1 and 3 of the original GSFQ, easily interpreted as referred to dyspepsia and not GERD, improved only marginally the diagnostic performance: AUROC 59.1%. Conclusion: The GSFQ does not predict results of pH monitoring in patients with typical symptoms in a tertiary care setting.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400002&lng=en&tlng=enEnfermedad por reflujo gastroesofágicopH-metría ambulatoriaSensibilidadEspecificidad |
| spellingShingle | Carlos Teruel-Sánchez-Vegazo Vicenta Faro-Leal Alfonso Muriel-García Norberto Mañas-Gallardo Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease Revista Espanola de Enfermedades Digestivas Enfermedad por reflujo gastroesofágico pH-metría ambulatoria Sensibilidad Especificidad |
| title | Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease |
| title_full | Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease |
| title_fullStr | Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease |
| title_full_unstemmed | Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease |
| title_short | Sensitivity and specificity of the Gastrointestinal Short Form Questionnaire in diagnosis of gastroesophageal reflux disease |
| title_sort | sensitivity and specificity of the gastrointestinal short form questionnaire in diagnosis of gastroesophageal reflux disease |
| topic | Enfermedad por reflujo gastroesofágico pH-metría ambulatoria Sensibilidad Especificidad |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000400002&lng=en&tlng=en |
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