Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial.
Objective: Withdrawal symptoms are a main reason of continuous use of opioid. This study compares the efficacy of augmentation of amantadine with clonidine in decreasing opioid withdrawal symptoms. Methods: This double-blind randomized clinical trial was carried out in the detoxification and rehabi...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2014-09-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/53 |
| _version_ | 1818980072179105792 |
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| author | Shahrokh Amiri Ayyoub Malek Farid Tofighnia Bohlool Habibi Asl Ali Seidy |
| author_facet | Shahrokh Amiri Ayyoub Malek Farid Tofighnia Bohlool Habibi Asl Ali Seidy |
| author_sort | Shahrokh Amiri |
| collection | DOAJ |
| description | Objective: Withdrawal symptoms are a main reason of continuous use of opioid. This study compares the efficacy of augmentation of amantadine with clonidine in decreasing opioid withdrawal symptoms.
Methods: This double-blind randomized clinical trial was carried out in the detoxification and rehabilitation inpatient ward at Razi Hospital, Tabriz, Iran during 2012. The patients were randomly assigned to receive clonidine or clonidine plus amantadine; and withdrawal symptoms were evaluated in the admission day and 24, 48, and 72 hours later. Data were analyzed using SPSS by the 2*2 repeated analyses of variances (ANOVA).
Results: From the total of 69 participants, 30 patients completed the trial in each group. The severity of symptoms, however, had an increasing trend in both groups. Analysis of variance of the symptom severity score (by The Clinical Opiate Withdrawal Scale) revealed a significant group-time interaction, and the patients who were receiving amantadine experienced milder symptoms .
Conclusions: Treatment of opioid withdrawal symptoms with amantadine and clonidine would result in a better outcome compared with clonidine alone. |
| first_indexed | 2024-12-20T17:09:36Z |
| format | Article |
| id | doaj.art-71861fa83dc048d7ac92407ca9d1bdbe |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-20T17:09:36Z |
| publishDate | 2014-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-71861fa83dc048d7ac92407ca9d1bdbe2022-12-21T19:32:11ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152014-09-019349Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial.Shahrokh Amiri0Ayyoub Malek1Farid Tofighnia2Bohlool Habibi Asl3Ali Seidy4Clinical psychiatry research center (CPRC), Tabriz University of medical sciences, Tabriz, IranClinical psychiatry research center (CPRC), Tabriz University of medical sciences, Tabriz, IranDepartment of psychiatry, Tabriz University of medical sciences, Tabriz, IranDepartment of Pharmacology, Tabriz University of Medical Sciences- Tabriz-IranDepartment of psychiatry, Tabriz University of medical sciences, Tabriz, IranObjective: Withdrawal symptoms are a main reason of continuous use of opioid. This study compares the efficacy of augmentation of amantadine with clonidine in decreasing opioid withdrawal symptoms. Methods: This double-blind randomized clinical trial was carried out in the detoxification and rehabilitation inpatient ward at Razi Hospital, Tabriz, Iran during 2012. The patients were randomly assigned to receive clonidine or clonidine plus amantadine; and withdrawal symptoms were evaluated in the admission day and 24, 48, and 72 hours later. Data were analyzed using SPSS by the 2*2 repeated analyses of variances (ANOVA). Results: From the total of 69 participants, 30 patients completed the trial in each group. The severity of symptoms, however, had an increasing trend in both groups. Analysis of variance of the symptom severity score (by The Clinical Opiate Withdrawal Scale) revealed a significant group-time interaction, and the patients who were receiving amantadine experienced milder symptoms . Conclusions: Treatment of opioid withdrawal symptoms with amantadine and clonidine would result in a better outcome compared with clonidine alone.https://ijps.tums.ac.ir/index.php/ijps/article/view/53AmantadineClonidineWithdrawal Syndrome |
| spellingShingle | Shahrokh Amiri Ayyoub Malek Farid Tofighnia Bohlool Habibi Asl Ali Seidy Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. Iranian Journal of Psychiatry Amantadine Clonidine Withdrawal Syndrome |
| title | Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. |
| title_full | Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. |
| title_fullStr | Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. |
| title_full_unstemmed | Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. |
| title_short | Amantadine as Augmentation in Managing Opioid Withdrawal with Clonidine: a randomized controlled trial. |
| title_sort | amantadine as augmentation in managing opioid withdrawal with clonidine a randomized controlled trial |
| topic | Amantadine Clonidine Withdrawal Syndrome |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/53 |
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