Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property
Porous titanium (P_Ti) is considered as an effective material for bone scaffold to achieve a stiffness reduction. Herein, biomimetic (bio-)scaffolds were made of sintered P_Ti, which used NaCl as the space holder and had it removed via the hydrothermal method. X-ray diffraction results showed that t...
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MDPI AG
2017-06-01
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| Online Access: | http://www.mdpi.com/1996-1944/10/7/726 |
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| author | Han Lee Jiunn-Der Liao Kundan Sivashanmugan Bernard Hao-Chih Liu Yu-Han Su Chih-Kai Yao Yung-Der Juang |
| author_facet | Han Lee Jiunn-Der Liao Kundan Sivashanmugan Bernard Hao-Chih Liu Yu-Han Su Chih-Kai Yao Yung-Der Juang |
| author_sort | Han Lee |
| collection | DOAJ |
| description | Porous titanium (P_Ti) is considered as an effective material for bone scaffold to achieve a stiffness reduction. Herein, biomimetic (bio-)scaffolds were made of sintered P_Ti, which used NaCl as the space holder and had it removed via the hydrothermal method. X-ray diffraction results showed that the subsequent sintering temperature of 1000 °C was the optimized temperature for preparing P_Ti. The compressive strength of P_Ti was measured using a compression test, which revealed an excellent load-bearing ability of above 70 MPa for that with an addition of 50 wt % NaCl (P_Ti_50). The nano-hardness of P_Ti, tested upon their solid surface, was presumably consistent with the density of pores vis-à-vis the addition of NaCl. Overall, a load-bearable P_Ti with a highly porous structure (e.g., P_Ti_50 with a porosity of 43.91% and a pore size around 340 μm) and considerable compressive strength could be obtained through the current process. Cell proliferation (MTS) and lactate dehydrogenase (LDH) assays showed that all P_Ti samples exhibited high cell affinity and low cell mortality, indicating good biocompatibility. Among them, P_Ti_50 showed relatively good in-cell morphology and viability, and is thus promising as a load-bearable bio-scaffold. |
| first_indexed | 2024-04-13T14:57:20Z |
| format | Article |
| id | doaj.art-7186ebffce614bdebbf93b90c76ab717 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-04-13T14:57:20Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-7186ebffce614bdebbf93b90c76ab7172022-12-22T02:42:24ZengMDPI AGMaterials1996-19442017-06-0110772610.3390/ma10070726ma10070726Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable PropertyHan Lee0Jiunn-Der Liao1Kundan Sivashanmugan2Bernard Hao-Chih Liu3Yu-Han Su4Chih-Kai Yao5Yung-Der Juang6Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 701, TaiwanDepartment of Materials Science, National University of Tainan, Tainan 700, TaiwanPorous titanium (P_Ti) is considered as an effective material for bone scaffold to achieve a stiffness reduction. Herein, biomimetic (bio-)scaffolds were made of sintered P_Ti, which used NaCl as the space holder and had it removed via the hydrothermal method. X-ray diffraction results showed that the subsequent sintering temperature of 1000 °C was the optimized temperature for preparing P_Ti. The compressive strength of P_Ti was measured using a compression test, which revealed an excellent load-bearing ability of above 70 MPa for that with an addition of 50 wt % NaCl (P_Ti_50). The nano-hardness of P_Ti, tested upon their solid surface, was presumably consistent with the density of pores vis-à-vis the addition of NaCl. Overall, a load-bearable P_Ti with a highly porous structure (e.g., P_Ti_50 with a porosity of 43.91% and a pore size around 340 μm) and considerable compressive strength could be obtained through the current process. Cell proliferation (MTS) and lactate dehydrogenase (LDH) assays showed that all P_Ti samples exhibited high cell affinity and low cell mortality, indicating good biocompatibility. Among them, P_Ti_50 showed relatively good in-cell morphology and viability, and is thus promising as a load-bearable bio-scaffold.http://www.mdpi.com/1996-1944/10/7/726porous titaniumbiomimetic scaffoldload bearablecell affinity |
| spellingShingle | Han Lee Jiunn-Der Liao Kundan Sivashanmugan Bernard Hao-Chih Liu Yu-Han Su Chih-Kai Yao Yung-Der Juang Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property Materials porous titanium biomimetic scaffold load bearable cell affinity |
| title | Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property |
| title_full | Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property |
| title_fullStr | Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property |
| title_full_unstemmed | Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property |
| title_short | Hydrothermal Fabrication of Highly Porous Titanium Bio-Scaffold with a Load-Bearable Property |
| title_sort | hydrothermal fabrication of highly porous titanium bio scaffold with a load bearable property |
| topic | porous titanium biomimetic scaffold load bearable cell affinity |
| url | http://www.mdpi.com/1996-1944/10/7/726 |
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