Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma
Abstract Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely understood. Whether obesity affects bone marrow immune cell composition in multiple myeloma is not characterized. Here, we examined...
| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Nature Portfolio
2024-02-01
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| coleção: | Scientific Reports |
| Acesso em linha: | https://doi.org/10.1038/s41598-024-54193-8 |
| _version_ | 1827327777232125952 |
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| author | Tonje Marie Vikene Nedal Siv Helen Moen Ingrid Aass Roseth Synne Stokke Tryggestad Kristin Roseth Aass Gunhild Garmo Hov Hanne Hella Anne-Marit Sponaas Therese Standal |
| author_facet | Tonje Marie Vikene Nedal Siv Helen Moen Ingrid Aass Roseth Synne Stokke Tryggestad Kristin Roseth Aass Gunhild Garmo Hov Hanne Hella Anne-Marit Sponaas Therese Standal |
| author_sort | Tonje Marie Vikene Nedal |
| collection | DOAJ |
| description | Abstract Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely understood. Whether obesity affects bone marrow immune cell composition in multiple myeloma is not characterized. Here, we examined the effect of diet-induced obesity on bone marrow immune cell composition and tumor growth in a Vk*MYC (Vk12653) transplant model of multiple myeloma. We find that diet-induced obesity promoted tumor growth in the bone marrow and spleen and reduced the relative number of T and B cells in the bone marrow. Our results suggest that obesity may reduce MM immune surveillance and thus may contribute to increased risk of developing MM. |
| first_indexed | 2024-03-07T15:07:16Z |
| format | Article |
| id | doaj.art-7186eef1b125426e8393cc0ca7ab52fe |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:07:16Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7186eef1b125426e8393cc0ca7ab52fe2024-03-05T18:51:01ZengNature PortfolioScientific Reports2045-23222024-02-011411710.1038/s41598-024-54193-8Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myelomaTonje Marie Vikene Nedal0Siv Helen Moen1Ingrid Aass Roseth2Synne Stokke Tryggestad3Kristin Roseth Aass4Gunhild Garmo Hov5Hanne Hella6Anne-Marit Sponaas7Therese Standal8Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Abstract Obesity is associated with an increased risk of developing multiple myeloma (MM). The molecular mechanisms causing this association is complex and incompletely understood. Whether obesity affects bone marrow immune cell composition in multiple myeloma is not characterized. Here, we examined the effect of diet-induced obesity on bone marrow immune cell composition and tumor growth in a Vk*MYC (Vk12653) transplant model of multiple myeloma. We find that diet-induced obesity promoted tumor growth in the bone marrow and spleen and reduced the relative number of T and B cells in the bone marrow. Our results suggest that obesity may reduce MM immune surveillance and thus may contribute to increased risk of developing MM.https://doi.org/10.1038/s41598-024-54193-8 |
| spellingShingle | Tonje Marie Vikene Nedal Siv Helen Moen Ingrid Aass Roseth Synne Stokke Tryggestad Kristin Roseth Aass Gunhild Garmo Hov Hanne Hella Anne-Marit Sponaas Therese Standal Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma Scientific Reports |
| title | Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma |
| title_full | Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma |
| title_fullStr | Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma |
| title_full_unstemmed | Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma |
| title_short | Diet-induced obesity reduces bone marrow T and B cells and promotes tumor progression in a transplantable Vk*MYC model of multiple myeloma |
| title_sort | diet induced obesity reduces bone marrow t and b cells and promotes tumor progression in a transplantable vk myc model of multiple myeloma |
| url | https://doi.org/10.1038/s41598-024-54193-8 |
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