Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Ai...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2015-10-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472400001009/type/journal_article |
| _version_ | 1811157096922611712 |
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| author | Rebecca Kerestes Pramit M. Phal Chris Steward Bradford A. Moffat Simon Salinas Kay L. Cox Kathryn A. Ellis Elizabeth V. Cyarto David Ames Ralph N. Martins Colin L. Masters Christopher C. Rowe Matthew J. Sharman Olivier Salvado Cassandra Szoeke Michelle Lai Nicola T. Lautenschlager Patricia M. Desmond |
| author_facet | Rebecca Kerestes Pramit M. Phal Chris Steward Bradford A. Moffat Simon Salinas Kay L. Cox Kathryn A. Ellis Elizabeth V. Cyarto David Ames Ralph N. Martins Colin L. Masters Christopher C. Rowe Matthew J. Sharman Olivier Salvado Cassandra Szoeke Michelle Lai Nicola T. Lautenschlager Patricia M. Desmond |
| author_sort | Rebecca Kerestes |
| collection | DOAJ |
| description |
Background
Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns.
Aims
To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele.
Method
Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored.
Results
ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity.
Conclusions
The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.
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| first_indexed | 2024-04-10T05:01:23Z |
| format | Article |
| id | doaj.art-718990d5360a4febb906748b723fcd17 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:01:23Z |
| publishDate | 2015-10-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-718990d5360a4febb906748b723fcd172023-03-09T12:28:35ZengCambridge University PressBJPsych Open2056-47242015-10-01113914810.1192/bjpo.bp.115.001339Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's diseaseRebecca Kerestes0Pramit M. Phal1Chris Steward2Bradford A. Moffat3Simon Salinas4Kay L. Cox5Kathryn A. Ellis6Elizabeth V. Cyarto7David Ames8Ralph N. Martins9Colin L. Masters10Christopher C. Rowe11Matthew J. Sharman12Olivier Salvado13Cassandra Szoeke14Michelle Lai15Nicola T. Lautenschlager16Patricia M. Desmond17Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USADepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, AustraliaDepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, AustraliaDepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, AustraliaDepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, AustraliaSchool of Medicine and Pharmacology, University of Western Australia, Perth, AustraliaAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, AustraliaNational Ageing Research Institute, University of Melbourne, Parkville, AustraliaAcademic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia and National Ageing Research Institute, University of Melbourne, Parkville, AustraliaSchool of Medical Sciences, Edith Cowan University, Perth, AustraliaThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, AustraliaDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, AustraliaSchool of Health Sciences, University of Tasmania, Hobart, AustraliaCommonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre, Brisbane, AustraliaNational Ageing Research Institute, University of Melbourne, Parkville, AustraliaNational Ageing Research Institute, University of Melbourne, Parkville, AustraliaAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, University of Melbourne, Melbourne, Australia and North Western Mental Health, Melbourne Health, Melbourne, AustraliaDepartment of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia Background Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. Aims To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE 4) allele. Method Participants were 22 SMC carrying the APOE ɛ4 allele (ɛ4+; mean age 72.18 years) and 58 SMC non-carriers (ɛ4–; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. Results ɛ4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC–SMA connectivity. Conclusions The results provide the first evidence that ɛ4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity. https://www.cambridge.org/core/product/identifier/S2056472400001009/type/journal_article |
| spellingShingle | Rebecca Kerestes Pramit M. Phal Chris Steward Bradford A. Moffat Simon Salinas Kay L. Cox Kathryn A. Ellis Elizabeth V. Cyarto David Ames Ralph N. Martins Colin L. Masters Christopher C. Rowe Matthew J. Sharman Olivier Salvado Cassandra Szoeke Michelle Lai Nicola T. Lautenschlager Patricia M. Desmond Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease BJPsych Open |
| title | Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease |
| title_full | Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease |
| title_fullStr | Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease |
| title_full_unstemmed | Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease |
| title_short | Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease |
| title_sort | alterations in dorsal and ventral posterior cingulate connectivity in apoe ε4 carriers at risk of alzheimer s disease |
| url | https://www.cambridge.org/core/product/identifier/S2056472400001009/type/journal_article |
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