Hyperinsulinemia in Obesity, Inflammation, and Cancer
The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationship...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Diabetes Association
2021-05-01
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| Series: | Diabetes & Metabolism Journal |
| Subjects: | |
| Online Access: | http://e-dmj.org/upload/pdf/dmj-2020-0250.pdf |
| _version_ | 1818609296467820544 |
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| author | Anni M.Y. Zhang Elizabeth A. Wellberg Janel L. Kopp James D. Johnson |
| author_facet | Anni M.Y. Zhang Elizabeth A. Wellberg Janel L. Kopp James D. Johnson |
| author_sort | Anni M.Y. Zhang |
| collection | DOAJ |
| description | The relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences of metabolic dysfunctions. Here, we review recent evidence demonstrating that hyperinsulinemia may play a role in inflammation, aging and development of cancers. In this review, we will focus on the consequences and mechanisms of excess insulin production and action, placing recent findings that have challenged dogma in the context of the existing body of literature. Where relevant, we elaborate on the role of specific signal transduction components in the actions of insulin and consequences of chronic hyperinsulinemia. By discussing the involvement of hyperinsulinemia in various metabolic and other chronic diseases, we may identify more effective therapeutics or lifestyle interventions for preventing or treating obesity, diabetes and cancer. We also seek to identify pertinent questions that are ripe for future investigation. |
| first_indexed | 2024-12-16T14:56:17Z |
| format | Article |
| id | doaj.art-718bc1047d3f4933bd7e8bad8cb30426 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-12-16T14:56:17Z |
| publishDate | 2021-05-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-718bc1047d3f4933bd7e8bad8cb304262022-12-21T22:27:25ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872021-05-0145328531110.4093/dmj.2020.02502547Hyperinsulinemia in Obesity, Inflammation, and CancerAnni M.Y. Zhang0Elizabeth A. Wellberg1Janel L. Kopp2James D. Johnson3 Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada Department of Pathology, University of Oklahoma Health Sciences Center, Stephenson Cancer Center, Harold Hamm Diabetes Center, Oklahoma City, OK, USA Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, BC, CanadaThe relative insufficiency of insulin secretion and/or insulin action causes diabetes. However, obesity and type 2 diabetes mellitus can be associated with an absolute increase in circulating insulin, a state known as hyperinsulinemia. Studies are beginning to elucidate the cause-effect relationships between hyperinsulinemia and numerous consequences of metabolic dysfunctions. Here, we review recent evidence demonstrating that hyperinsulinemia may play a role in inflammation, aging and development of cancers. In this review, we will focus on the consequences and mechanisms of excess insulin production and action, placing recent findings that have challenged dogma in the context of the existing body of literature. Where relevant, we elaborate on the role of specific signal transduction components in the actions of insulin and consequences of chronic hyperinsulinemia. By discussing the involvement of hyperinsulinemia in various metabolic and other chronic diseases, we may identify more effective therapeutics or lifestyle interventions for preventing or treating obesity, diabetes and cancer. We also seek to identify pertinent questions that are ripe for future investigation.http://e-dmj.org/upload/pdf/dmj-2020-0250.pdfbreast neoplasmsdiabetes mellitus, type 2insulinlongevitymetabolic syndromepancreatic neoplasms |
| spellingShingle | Anni M.Y. Zhang Elizabeth A. Wellberg Janel L. Kopp James D. Johnson Hyperinsulinemia in Obesity, Inflammation, and Cancer Diabetes & Metabolism Journal breast neoplasms diabetes mellitus, type 2 insulin longevity metabolic syndrome pancreatic neoplasms |
| title | Hyperinsulinemia in Obesity, Inflammation, and Cancer |
| title_full | Hyperinsulinemia in Obesity, Inflammation, and Cancer |
| title_fullStr | Hyperinsulinemia in Obesity, Inflammation, and Cancer |
| title_full_unstemmed | Hyperinsulinemia in Obesity, Inflammation, and Cancer |
| title_short | Hyperinsulinemia in Obesity, Inflammation, and Cancer |
| title_sort | hyperinsulinemia in obesity inflammation and cancer |
| topic | breast neoplasms diabetes mellitus, type 2 insulin longevity metabolic syndrome pancreatic neoplasms |
| url | http://e-dmj.org/upload/pdf/dmj-2020-0250.pdf |
| work_keys_str_mv | AT annimyzhang hyperinsulinemiainobesityinflammationandcancer AT elizabethawellberg hyperinsulinemiainobesityinflammationandcancer AT janellkopp hyperinsulinemiainobesityinflammationandcancer AT jamesdjohnson hyperinsulinemiainobesityinflammationandcancer |