Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf
<i>Calendula officinalis</i> is commonly known as marigold and its flowers are used in herbal medicines, cosmetics, perfumes, dyes, pharmaceutical preparations, and food products. However, the utility of its leaves has not been studied in depth. The purpose of the present study was to id...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/3/1333 |
| _version_ | 1797623692480479232 |
|---|---|
| author | Wataru Kadowaki Ryo Miyata Misa Fujinami Yoshizumi Sato Shigenori Kumazawa |
| author_facet | Wataru Kadowaki Ryo Miyata Misa Fujinami Yoshizumi Sato Shigenori Kumazawa |
| author_sort | Wataru Kadowaki |
| collection | DOAJ |
| description | <i>Calendula officinalis</i> is commonly known as marigold and its flowers are used in herbal medicines, cosmetics, perfumes, dyes, pharmaceutical preparations, and food products. However, the utility of its leaves has not been studied in depth. The purpose of the present study was to identify the major compounds in <i>C. officinalis</i> leaves and to determine the inhibitory properties of the isolated compounds toward human catechol-<i>O</i>-methyltransferase (COMT), a key neurotransmitter involved in Parkinson’s disease and depression. We isolated and identified ten compounds, including two phenylpropanoids and seven flavonoids, from <i>C. officinalis</i> leaf extracts, of which four flavonoids were identified from <i>C. officinalis</i> leaves for the first time. Eight compounds exhibited COMT inhibitory activities with IC<sub>50</sub> values of less than 100 μM. Our results indicate that compounds in <i>C. officinalis</i> leaves are potentially effective for preventing Parkinson’s disease and depression. Thus, <i>C. officinalis</i> leaves may hold promise as dietary supplements. |
| first_indexed | 2024-03-11T09:32:24Z |
| format | Article |
| id | doaj.art-718dffab8b6c4532a37c2451bf55c869 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T09:32:24Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-718dffab8b6c4532a37c2451bf55c8692023-11-16T17:30:58ZengMDPI AGMolecules1420-30492023-01-01283133310.3390/molecules28031333Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> LeafWataru Kadowaki0Ryo Miyata1Misa Fujinami2Yoshizumi Sato3Shigenori Kumazawa4Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, JapanKisho Corporation Co., Ltd., 3-4-27 Kitasuna, Koto-ku, Tokyo 136-0073, JapanKisho Corporation Co., Ltd., 3-4-27 Kitasuna, Koto-ku, Tokyo 136-0073, JapanGraduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan<i>Calendula officinalis</i> is commonly known as marigold and its flowers are used in herbal medicines, cosmetics, perfumes, dyes, pharmaceutical preparations, and food products. However, the utility of its leaves has not been studied in depth. The purpose of the present study was to identify the major compounds in <i>C. officinalis</i> leaves and to determine the inhibitory properties of the isolated compounds toward human catechol-<i>O</i>-methyltransferase (COMT), a key neurotransmitter involved in Parkinson’s disease and depression. We isolated and identified ten compounds, including two phenylpropanoids and seven flavonoids, from <i>C. officinalis</i> leaf extracts, of which four flavonoids were identified from <i>C. officinalis</i> leaves for the first time. Eight compounds exhibited COMT inhibitory activities with IC<sub>50</sub> values of less than 100 μM. Our results indicate that compounds in <i>C. officinalis</i> leaves are potentially effective for preventing Parkinson’s disease and depression. Thus, <i>C. officinalis</i> leaves may hold promise as dietary supplements.https://www.mdpi.com/1420-3049/28/3/1333<i>Calendula officinalis</i>flavonoidphenylpropanoidcatechol-<i>O</i>-methyltransferaseParkinson’s disease |
| spellingShingle | Wataru Kadowaki Ryo Miyata Misa Fujinami Yoshizumi Sato Shigenori Kumazawa Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf Molecules <i>Calendula officinalis</i> flavonoid phenylpropanoid catechol-<i>O</i>-methyltransferase Parkinson’s disease |
| title | Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf |
| title_full | Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf |
| title_fullStr | Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf |
| title_full_unstemmed | Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf |
| title_short | Catechol-<i>O</i>-methyltransferase Inhibitors from <i>Calendula officinalis</i> Leaf |
| title_sort | catechol i o i methyltransferase inhibitors from i calendula officinalis i leaf |
| topic | <i>Calendula officinalis</i> flavonoid phenylpropanoid catechol-<i>O</i>-methyltransferase Parkinson’s disease |
| url | https://www.mdpi.com/1420-3049/28/3/1333 |
| work_keys_str_mv | AT watarukadowaki catecholioimethyltransferaseinhibitorsfromicalendulaofficinalisileaf AT ryomiyata catecholioimethyltransferaseinhibitorsfromicalendulaofficinalisileaf AT misafujinami catecholioimethyltransferaseinhibitorsfromicalendulaofficinalisileaf AT yoshizumisato catecholioimethyltransferaseinhibitorsfromicalendulaofficinalisileaf AT shigenorikumazawa catecholioimethyltransferaseinhibitorsfromicalendulaofficinalisileaf |